Evidence map›Paper›PMID 38079206›Full record

ArticleeLife2023

Allelic strengths of encephalopathy-associated

Xueyang Pan, Albert N Alvarez, Mengqi Ma, Shenzhao Lu, Michael W Crawford, Lauren C Briere, Oguz Kanca, Shinya Yamamoto, David A Sweetser, Jenny L Wilson and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Autobehaver: An AI-Based Pipeline for Animal Behavior Analysis.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Functional assays inGenome research · 2025
    Review
  6. Review
  7. Insects · 2024
    Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Xueyang PanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0003-4453-4971
Albert N AlvarezDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, United States.
Mengqi MaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Shenzhao LuDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0003-3117-3900
Michael W CrawfordDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, United States.ORCID 0000-0001-7779-4636
Lauren C BriereCenter for Genomic Medicine, Massachusetts General Hospital, Boston, United States.
Oguz KancaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Shinya YamamotoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
David A SweetserCenter for Genomic Medicine, Massachusetts General Hospital, Boston, United States.ORCID 0000-0002-1621-3284
Jenny L WilsonDivision of Pediatric Neurology, Department of Pediatrics, Oregon Health & Science University, Portland, United States.
Ruth J NapierDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, United States.
Jonathan N PrunedaDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, United States.ORCID 0000-0002-0304-4418
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-5992-5989
Baylor College of Medicine · USOregon Health & Science University · USMassachusetts General Hospital · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
UNDERSTANDING FXTAS AMONG MALES WITH THE FMR1 PREMUTATIONP30HD024064 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ROSENMUND, CHRISTIAN · 1988 to 2013
$29.4M
Resource and Service SectionU54OD030165 · OD · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney · 2020 to 2026
$16.6M
Center for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Expansion and characterization of the Drosophila Toolkit to study SARS-CoV-2R24OD022005 · OD · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2016 to 2023
$7.4M
A Comprehensive Resource for Manipulating the Drosophila GenomeR24OD031447 · OD · BAYLOR COLLEGE OF MEDICINE · PI HUGO J BELLEN, Oguz Kanca · 2021 to 2026
$5.2M
Exploiting bacterial effector proteins to study human ubiquitin signalingR35GM142486 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jonathan N Pruneda · 2021 to 2026
$2.6M
BLRD VA IK2 BX004523NCATS NIH HHS UL1 TR002369NHGRI NIH HHS U01 HG007690NICHD NIH HHS P30 HD024064NICHD NIH HHS P50 HD103555NIGMS NIH HHS R35 GM142486NIH HHS R24 OD022005NIH HHS R24 OD031447NIH HHS U54 OD030165ODCDC CDC HHS R24 OD022005ODCDC CDC HHS R24 OD031447ODCDC CDC HHS U54 OD030165
6 · The paper itself

Abstract

Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in development and endoplasmic reticulum stress. Variants in the

Indexed as

Brain DiseasesIntellectual DisabilityMovement DisordersUbiquitin-Activating EnzymesDrosophilaDrosophila ProteinsHumansMutation, MissenseDrosophila ProteinsUBA5 protein, humanUbiquitin-Activating Enzymesallelic seriesdevelopmental and epileptic encephalopathyD. melanogastergeneticsgenomicshumanmedicinerare diseaseUBA5UFMylation

Identifiers

PMID38079206
PMCPMC10712953
OpenAlexW4385664547

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.