Evidence map›Paper›PMID 38079196›Full record

ArticleJMIR medical informatics2023

Extending cBioPortal for Therapy Recommendation Documentation in Molecular Tumor Boards: Development and Usability Study.

Christopher Renner, Niklas Reimer, Jan Christoph, Hauke Busch, Patrick Metzger, Melanie Boerries, Arsenij Ustjanzew, Dominik Boehm, Philipp Unberath

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In one paragraph

Article in JMIR medical informatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher RennerChair of Medical Informatics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.ORCID https://orcid.org/0009-0001-7537-3931
Niklas ReimerGroup for Medical Systems Biology, Lübeck Institute of Experimental, Universität zu Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0002-0491-3929
Jan ChristophChair of Medical Informatics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.ORCID https://orcid.org/0000-0003-4369-3591
Hauke BuschGroup for Medical Systems Biology, Lübeck Institute of Experimental, Universität zu Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0003-4763-4521
Patrick MetzgerInstitute of Medical Bioinformatics and Systems Medicine, University of Freiburg Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-2451-1943
Melanie BoerriesInstitute of Medical Bioinformatics and Systems Medicine, University of Freiburg Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-3670-0602
Arsenij UstjanzewInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.ORCID https://orcid.org/0000-0002-1014-4521
Dominik BoehmMedical Center for Information and Communication Technology, Universitätsklinikum Erlangen, Erlangen, Germany.ORCID https://orcid.org/0009-0001-2887-7109
Philipp UnberathChair of Medical Informatics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.ORCID https://orcid.org/0000-0002-1269-9360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn molecular tumor boards (MTBs), patients with rare or advanced cancers are discussed by a multidisciplinary team of health care professionals. Software support for MTBs is lacking; in particular, tools for preparing and documenting MTB therapy recommendations need to be developed.

objectiveWe aimed to implement an extension to cBioPortal to provide a tool for the documentation of therapy recommendations from MTB sessions in a secure and standardized manner. The developed extension should be embedded in the patient view of cBioPortal to enable easy documentation during MTB sessions. The resulting architecture for storing therapy recommendations should be integrable into various hospital information systems.

methodsOn the basis of a requirements analysis and technology analysis for authentication techniques, a prototype was developed and iteratively refined through a user-centered development process. In conclusion, the tool was evaluated via a usability evaluation, including interviews, structured questionnaires, and the System Usability Scale.

resultsThe patient view of cBioPortal was extended with a new tab that enables users to document MTB sessions and therapy recommendations. The role-based access control was expanded to allow for a finer distinction among the rights to view, edit, and delete data. The usability evaluation showed overall good usability and a System Usability Scale score of 83.57.

conclusionsThis study demonstrates how cBioPortal can be extended to not only visualize MTB patient data but also be used as a documentation platform for therapy recommendations.

Indexed as

cancercBioPortaldevelopmentdocumentation platformgenomicshealth information interoperabilityimplementationmolecular tumor boardplatformprecisionprecision medicinetooltumorusability evaluationuseuser-centered

Identifiers

PMID38079196
PMCPMC10750236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.