Evidence map›Paper›PMID 38079194›Full record

ArticleTherapeutic hypothermia and temperature management2024

Intra Operative Mild Cooling of Large Tumors Reduces Their Invasive and Metastatic Functions While Increasing Their Resistance to Apoptosis.

Noureddin Tavassoli, Alireza Ghahremani, Kosar Namakin, Alvand Naserghandi, Seyed Rouhollah Miri, Mohammad Abdolahad

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic hypothermia and temperature management, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Noureddin TavassoliCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
Alireza GhahremaniNano Bio Electronic Devices Lab, Nano Electronic Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Kosar NamakinNano Bio Electronic Devices Lab, Nano Electronic Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Alvand NaserghandiNano Bio Electronic Devices Lab, Nano Electronic Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.ORCID 0000-0003-2071-5321
Seyed Rouhollah MiriCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad AbdolahadNano Bio Electronic Devices Lab, Nano Electronic Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.
University of Tehran · IRMotamed Cancer Institute · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer treatment often involves excisional surgery, but this approach may leave behind minimal residual disease, leading to tumor regrowth. Proinflammatory cytokines and their role in altering residual cancerous cells postsurgery have garnered attention. The study examines how mild intraoperative cooling affects cancer cells and their gene expression. It aims to discover strategies for reducing tumor growth after surgery. Nine cases of solid tumor were included in the study, nine samples were cooled with the Peltier-Seebeck device down to12°C, and cooled and noncooled regions of tumors were analyzed using reverse transcription-polymerase chain reaction. Key transcriptomes, including neural-cadherin, cadherins (

Indexed as

ApoptosisHypothermia, InducedNeoplasm InvasivenessNeoplasmsAgedCadherinsFemaleGene Expression Regulation, NeoplasticHumansIntraoperative CareMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Middle AgedY-Box-Binding Protein 1CadherinsMatrix Metalloproteinase 2Matrix Metalloproteinase 9MMP2 protein, humanMMP9 protein, humanY-Box-Binding Protein 1YBX1 protein, humanapoptosiscancerhypothermiametastasissurgery

Identifiers

PMID38079194
PMCPMC11665270
OpenAlexW4389551072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.