Evidence map›Paper›PMID 38079001›Full record

ArticleEJNMMI physics2023

SLIC-Occ: functional segmentation of occupancy images improves precision of EC

Alaaddin Ibrahimy, Jocelyn Hoye, Hao Wu, Bart de Laat, Su Jin Kim, David L Wilson, Evan D Morris

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alaaddin IbrahimyDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA. alaaddin.ibrahimy@yale.edu.ORCID http://orcid.org/0000-0003-2358-9260
Jocelyn HoyeDepartment of Radiology, Yale University, New Haven, CT, USA.
Hao WuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Bart de LaatDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Su Jin KimDepartment of Nuclear Medicine, Seoul National University Budang Hospital, Seongnam, South Korea.
David L WilsonDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Evan D MorrisDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0009-0003-1422-4523
Yale University · USCase Western Reserve University · USSeoul National University Bundang Hospital · KR

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Validation of Occupancy Images from PET Data. A Novel Endpoint for Drug DiscoveryR01EB032658 · NIBIB · YALE UNIVERSITY · PI MORRIS, EVAN D · 2022 to 2025
$2.4M
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS R01 EB032658NIBIB NIH HHS R01EB032658
6 · The paper itself

Abstract

backgroundDrug occupancy studies with positron emission tomography imaging are used routinely in early phase drug development trials. Recently, our group introduced the Lassen Plot Filter, an extended version of the standard Lassen plot to estimate voxel-level occupancy images. Occupancy images can be used to create an EC

methodA digital brain phantom was used to create 10 occupancy images (corresponding to 10 different plasma concentrations of drug) that correspond to a ground truth EC

resultsVariability in EC

conclusionsOur results suggest that functional segmentation of occupancy images via SLIC-Occ could produce more precise EC

Indexed as

Accuracy and precisionBrain imagingDrug occupancyEC50 imagesFunctional clusteringPET simulation

Identifiers

PMID38079001
PMCPMC10713928
OpenAlexW4389566063

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.