ArticlemBio2024
Liberation of host heme by
Abstract read
In one paragraph
Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Acidification-dependent suppression ofInfection and immunity · 2026Article
- Contact dependent suppression ofbioRxiv : the preprint server for biology · 2026Article
- Acidification-dependent suppression ofbioRxiv : the preprint server for biology · 2026Article
- Deoxycholate induces proline provision from Escherichia coli to enhance Clostridioides difficile virulence.The ISME journal · 2026Article
- Heme in Bacterial Pathogenesis and as an Antimicrobial Target.Chemical reviews · 2025Review
- The exploitation of nutrient metals by bacteria for survival and infection in the gut.PLoS pathogens · 2025Review
- Dietary Fiber Modulates the Window of Susceptibility to Clostridioides difficile Infection.Gastroenterology · 2025Article
- Host niche-specific challenges hindering the treatment of polymicrobial infections.Journal of bacteriology · 2025Review
- Discovery of a Widespread Polyamine-Low-Molecular-Weight Thiol Hybrid Pathway inACS infectious diseases · 2025Article
- Article
- Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium.Nature microbiology · 2025Article
- A Novel Heme-Degrading Enzyme that Regulates Heme and Iron Homeostasis and Promotes Virulence inbioRxiv : the preprint server for biology · 2025Article
- Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization.Cell host & microbe · 2025Article
- Metals in the gut: microbial strategies to overcome nutritional immunity in the intestinal tract.Metallomics : integrated biometal science · 2024Review
- Bacteriocin production facilitates nosocomial emergence of vancomycin-resistantmedRxiv : the preprint server for health sciences · 2024Article
- Heme utilization by the enterococci.FEMS microbes · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Alexander B SmithDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-5407-0141
Jonathan T SpeckerDepartment of Chemistry, University of Florida, Gainesville, Florida, USA.
Katharine K HewlettDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0009-0008-1311-5049
Troy R ScogginsDepartment of Chemistry, University of Florida, Gainesville, Florida, USA.
Montana KnightDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Abigail M LustigDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Yanhong LiDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kirsten M EvansDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Yingchan GuoDepartment of Chemistry, University of Florida, Gainesville, Florida, USA.
Qianxuan SheDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Michael W ChristopherDepartment of Chemistry, University of Florida, Gainesville, Florida, USA.
Timothy J GarrettDepartment of Chemistry, University of Florida, Gainesville, Florida, USA.
Ahmed M MoustafaDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Daria Van TyneDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7284-0103
Boone M PrenticeDepartment of Chemistry, University of Florida, Gainesville, Florida, USA.
Joseph P ZackularDivision of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3228-3055
Funding
Project 3: Defining adaptive immune interactions that shape Clostridioides difficile infectionU19AI174998 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DREW WEISSMAN · 2023 to 2026
$7.6MAdaptation of vancomycin-resistant enterococci during bloodstream infectionR01AI165519 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2022 to 2025
$3.0MMolecular interactions in the gut microbiota during early life colonization and perturbationR35GM138369 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph Paul Zackular · 2020 to 2026
$2.7MDeciphering the genetic basis of differential antibiotic efficacy in Enterococcus faecalis endocarditisR21AI164018 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2022 to 2023
$436kThe Impact of Vancomycin-Resistant Entercoccus on Clostridium difficile InfectionK22AI137220 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI ZACKULAR, JOSEPH PAUL · 2019 to 2020
$270kCarbonic anhydrase inhibition as a target for antibiotic synergy in enterococciR03AI168491 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2023 to 2024
$159kNIAID NIH HHS K22 AI137220NIAID NIH HHS L40 AI147162NIAID NIH HHS R01 AI165519NIAID NIH HHS R03 AI168491NIAID NIH HHS R21 AI164018NIAID NIH HHS U19 AI174998NIGMS NIH HHS R35 GM138369
Abstract
importance
Indexed as
Clostridioides difficileClostridium InfectionsGastrointestinal MicrobiomeBacteriaEnterococcus faecalisHumansClostridioides difficileEnterococcusgut microbiomehemeinfectious diseasemicrobial ecology
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.