Evidence map›Paper›PMID 38078745›Full record

ArticlemSphere2024

Microbiota-mediated effects of Parkinson's disease medications on Parkinsonian non-motor symptoms in male transgenic mice.

Nina Radisavljevic, Avril Metcalfe-Roach, Mihai Cirstea, M Mahebali Tabusi, Tahereh Bozorgmehr, Haggai Bar-Yoseph, B Brett Finlay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nina RadisavljevicMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-9955-2029
Avril Metcalfe-RoachMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Mihai CirsteaMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
M Mahebali TabusiMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Tahereh BozorgmehrMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Haggai Bar-YosephMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
B Brett FinlayMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-5303-6128
University of British Columbia · CA

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) FDN-159935
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by motor symptoms and a loss of dopaminergic neurons, as well as a variety of non-motor symptoms, including constipation, depression, and anxiety. Recently, evidence has also accumulated for a link between gut microbiota and PD. Most PD patients are on dopamine replacement therapy, primarily a combination of L-DOPA and carbidopa; however, the effect of these medications on the microbiota and non-motor symptoms in PD is still unclear. In this study, we explored the effects of chronic oral treatment with L-DOPA plus carbidopa (LDCD) on the gut microbiota and non-motor symptoms in males of a transgenic mouse model of PD (dbl-PAC-Tg(

Indexed as

Gastrointestinal MicrobiomeParkinson DiseaseAnimalsAnti-Bacterial AgentsCarbidopaConstipationDopamineHumansLevodopaMaleMiceMice, TransgenicAnti-Bacterial AgentsCarbidopaDopamineLevodopaanimal modelsgut-brain axisgut microbiomegut microbiotagut-microbiota-brain axismouse modelneurodegenerative diseaseParkinson's disease

Identifiers

PMID38078745
PMCPMC10826342
OpenAlexW4389558793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.