Evidence map›Paper›PMID 38077473›Full record

ArticleJournal of orthopaedics2024

Spinal fusion of biodegradable poly(propylene fumarate) and poly(propylene fumarate-co-caprolactone) copolymers in rabbits.

Hao Xu, Hui Liao, Xifeng Liu, A Lee Miller, Benjamin D Elder, Lichun Lu

Open access · greenAbstract read
In one paragraph

Article in Journal of orthopaedics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hao XuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.
Hui LiaoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.
Xifeng LiuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.
A Lee MillerDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Benjamin D ElderDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.
Lichun LuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.
Mayo Clinic in Arizona · USMayo Clinic · US

Funding

Metastatic Spine Tumors: Minimally Invasive Fracture Risk Analysis and Treatment - MasterR01AR056212 · NIAMS · MAYO CLINIC ROCHESTER · PI Benjamin D Elder, Lichun Lu · 2008 to 2026
$6.2M
Injectable and Moldable Composite Bone Scaffolds for Spinal FusionR01AR075037 · NIAMS · MAYO CLINIC ROCHESTER · PI ELDER, BENJAMIN D, LU, LICHUN · 2019 to 2023
$2.5M
NIAMS NIH HHS R01 AR056212NIAMS NIH HHS R01 AR075037
6 · The paper itself

Abstract

Background: Autologous bone grafts are currently the standard in orthopedic surgery despite limited donor sources and the prevalence of donor site morbidity. Other alternatives such as allografts are more readily available than autografts but have lower rates of graft incorporation. Methods: Here, we propose a novel graft alternative consisting of an injectable poly(propylene fumarate) (PPF) and poly(propylene fumarate-co-caprolactone) P(PF- Results: Of the 4 experimental groups, the injectable P(PF- Conclusion: Injectable P(PF-co-CL) polymers showed promising spine fusion abilities in rabbits after 12 weeks of posterolateral implantation.

Indexed as

Injectable scaffoldpoly(propylene fumarate)Posterolateral spinal fusion

Identifiers

PMID38077473
PMCPMC10700862
OpenAlexW4388191368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.