Evidence map›Paper›PMID 38077434›Full record

ArticlePeerJ2023

Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing the transcription and splicing of tumorigenesis-related genes.

Qingchao Sun, Ruixue Liu, Haiping Zhang, Liang Zong, Xiaoliang Jing, Long Ma, Jie Li, Liwei Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. LncRNAs in modulating cancer cell resistance to paclitaxel (PTX) therapy.Medical oncology (Northwood, London, England) · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qingchao SunDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinshi District, China.
Ruixue LiuDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinshi District, China.
Haiping ZhangDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinshi District, China.
Liang ZongDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinshi District, China.
Xiaoliang JingDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinshi District, China.
Long MaDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinshi District, China.
Jie LiDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinshi District, China.
Liwei ZhangDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinshi District, China.
First Affiliated Hospital of Xinjiang Medical University · CNXinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: High mortality rates are prevalent among patients with non-small-cell lung cancer (NSCLC), and effective therapeutic targets are key prognostic factors. Fascin actin-bundling protein 1 (FSCN1) promotes NSCLC; however, its role as an RNA-binding protein in NSCLC remains unexplored. Therefore, we aimed to explore FSCN1 expression and function in A549 cells. Method: We screened for alternative-splicing events and differentially expressed genes (DEGs) after Results: Silencing

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsMicroRNAsActinsCalcium-Binding ProteinsCarcinogenesisCarrier ProteinsCell Cycle ProteinsCell Line, TumorCell MovementCell Transformation, NeoplasticHumansMicrofilament ProteinsNuclear ProteinsPeptide Elongation Factor 1RecQ HelicasesActinsBCCIP protein, humanCalcium-Binding ProteinsCarrier ProteinsCell Cycle ProteinsEEF1D protein, humanfascinFSCN1 protein, humanMicrofilament ProteinsMicroRNAsNuclear ProteinsPeptide Elongation Factor 1RecQ HelicasesRECQL5 protein, humanRNA PrecursorsAlternative splicingFSCN1NSCLCRNA-binding proteinTranscription

Identifiers

PMID38077434
PMCPMC10704988
OpenAlexW4389341055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.