Evidence map›Paper›PMID 38077381›Full record

ArticleFrontiers in immunology2023

Adoptive transfer of allergen-expressing B cells prevents IgE-mediated allergy.

Lisa Prickler, Ulrike Baranyi, Konstantinos Mengrelis, Anna Marianne Weijler, Verena Kainz, Bernhard Kratzer, Romy Steiner, Jasmin Mucha, Elisa Rudoph, Nina Pilat and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Lisa PricklerDivision of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Ulrike BaranyiCardiac Surgery Research Laboratory, Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Konstantinos MengrelisDivision of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Anna Marianne WeijlerDivision of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Verena KainzDivision of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Bernhard KratzerInstitute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Romy SteinerDivision of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Jasmin MuchaDivision of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Elisa RudophDivision of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Nina PilatDivision of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Barbara BohleDepartment of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Herbert StroblDivision of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
Winfried Franz PicklInstitute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Rudolf ValentaDepartment of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Birgit LinhartDepartment of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Thomas WekerleDivision of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATFederal Medical-Biological Agency · RUMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Prophylactic strategies to prevent the development of allergies by establishing tolerance remain an unmet medical need. We previously reported that the transfer of autologous hematopoietic stem cells (HSC) expressing the major timothy grass pollen allergen, Phl p 5, on their cell surface induced allergen-specific tolerance in mice. In this study, we investigated the ability of allergen-expressing immune cells (dendritic cells, CD4 Methods: For this purpose, CD19 Results: The transfer of purified Phl p 5-expressing CD19 Discussion: Thus, we demonstrated that the transfer of Phl p 5-expressing CD19

Indexed as

AllergensHypersensitivityAdoptive TransferAnimalsCD8-Positive T-LymphocytesHumansImmunoglobulin EImmunoglobulin GMiceMice, TransgenicAllergensImmunoglobulin EImmunoglobulin Gallergycell therapychimerismprophylaxistolerance

Identifiers

PMID38077381
PMCPMC10703460
OpenAlexW4388946694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.