ArticleFrontiers in immunology2023
Comprehensive analysis of the association between inflammation indexes and complications in patients undergoing pancreaticoduodenectomy.
Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 8 citations in OpenAlex.
- Predictive Value of the ALBI Grade for Short-Term Morbidity and Mortality After Pancreatoduodenectomy.Cancers · 2026Article
- Perioperative changes in systemic inflammatory markers predict major complications after distal pancreatectomy.Updates in surgery · 2026Article
- Construction of a predictive model for postoperative pancreatic fistula following pancreaticoduodenectomy and an exploration of inflammatory biomarker associations.Gland surgery · 2026Article
- Clinical phenotyping of polymyxin-associated nephrotoxicity and phenotype-specific prognostic utility of neutrophil-to-platelet ratio in carbapenem-resistant Acinetobacter baumannii infections.BMC infectious diseases · 2026Article
- The impact of individualized short-term prehabilitation on perioperative complications and inflammatory markers in pancreaticoduodenectomy: a single-center historical cohort study.Frontiers in medicine · 2026Article
- Dynamic platelet count value as a clinical indicator of postoperative pancreatic fistula after pancreatic resections.Przeglad gastroenterologiczny · 2026Article
- Multi-Indicator analysis of the impact of preoperative inflammatory states on complications following pancreatoduodenectomy.Langenbeck's archives of surgery · 2025Article
- The Value of Blood T Cell Frequencies for Risk Prediction of Postoperative Complications in Pancreatic Cancer Surgery.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Preoperative systemic inflammatory biomarkers can improve recurrence prediction of non-muscle invasive bladder cancer after endoscopic resection - a prospective observational study.Contemporary oncology (Poznan, Poland) · 2025Article
- Association between blood inflammatory status and the survival of tuberculosis: a five-year cohort study.Frontiers in immunology · 2025Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: During clinical practice, routine blood tests are commonly performed following pancreaticoduodenectomy (PD). However, the relationship between blood cell counts, inflammation-related indices, and postoperative complications remains unclear. Method: We conducted a retrospective study, including patients who underwent PD from October 2018 to July 2023 at the First Hospital of Chongqing Medical University, and compared baseline characteristics and clinical outcomes among different groups. Neutrophil count (NC), platelet count (PLT), lymphocyte count (LC), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and the product of platelet count and neutrophil count (PPN) were derived from postoperative blood test results. We investigated the association between these indicators and outcomes using multivariable logistic regression and restricted cubic spline analysis. The predictive performance of these indicators was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and decision curve analysis (DCA). Result: A total of 232 patients were included in this study. Multivariate logistic regression and restricted cubic spline analysis showed that all indicators, except for PLT, were associated with clinical postoperative pancreatic fistula (POPF). SII, NLR, and NC were linked to surgical site infection (SSI), while SII, NLR, and PLR were correlated with CD3 complication. PLT levels were related to postoperative hemorrhage. SII (AUC: 0.729), NLR (AUC: 0.713), and NC (AUC: 0.706) effectively predicted clinical POPF. Conclusion: In patients undergoing PD, postoperative inflammation-related indices and blood cell counts are associated with various complications. NLR and PLT can serve as primary indicators post-surgery for monitoring complications.
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