Evidence map›Paper›PMID 38077228›Full record

ArticleMediators of inflammation2023

Comparison of Inflammatory Cytokine Levels in Hepatic and Jugular Veins of Patients with Cirrhosis.

Leonard Kaps, Carolina Medina-Montano, Matthias Bros, Stephan Grabbe, Simon Johannes Gairing, Eva M Schleicher, Stephan Gehring, Jörn M Schattenberg, Peter R Galle, Marcus-Alexander Wörns and 2 more

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Gut Microbiota and Cytokine Profile in Cirrhosis.Journal of clinical and translational hepatology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Leonard KapsDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.ORCID https://orcid.org/0000-0002-4782-8003
Carolina Medina-MontanoDepartment of Dermatology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Matthias BrosDepartment of Dermatology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Stephan GrabbeDepartment of Dermatology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Simon Johannes GairingDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Eva M SchleicherDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Stephan GehringDepartment of Paediatrics, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Jörn M SchattenbergDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Peter R GalleDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Marcus-Alexander WörnsDepartment of Gastroenterology, Hematology, Oncology and Endocrinology, Klinikum Dortmund, Dortmund, Germany.
Michael NagelDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
Christian LabenzDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.ORCID https://orcid.org/0000-0001-8390-9663
Johannes Gutenberg University Mainz · DEKlinikum Dortmund · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Systemic inflammation with elevated inflammatory cytokines is a hallmark in patients with cirrhosis and the main driver of decompensation. There is insufficient data on whether inflammatory cytokine levels differ between hepatic and jugular veins, which may have implications for further immunological studies. Methods: Blood from the hepatic and jugular veins of 40 patients with cirrhosis was collected during hepatic venous pressure gradient (HVPG) measurements. Serum levels of 13 inflammatory cytokines (IL-1 Results: Cytokine levels of IFN- Conclusion: Cytokine levels increase with decompensation and increasing portal hypertension in patients with cirrhosis. There is no relevant difference in cytokine levels between hepatic and jugular blood in patients with cirrhosis.

Indexed as

Hypertension, PortalInterleukin-10CytokinesHumansInterleukin-17Interleukin-18Interleukin-23Interleukin-33Interleukin-6Interleukin-8Jugular VeinsLiver CirrhosisTumor Necrosis Factor-alphaCytokinesInterleukin-10Interleukin-17Interleukin-18Interleukin-23Interleukin-33Interleukin-6Interleukin-8Tumor Necrosis Factor-alpha

Identifiers

PMID38077228
PMCPMC10700970
OpenAlexW4389155092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.