Evidence map›Paper›PMID 38077130›Full record

ReviewiScience2023

Integrating mechanical cues with engineered platforms to explore cardiopulmonary development and disease.

Donia W Ahmed, Madeline K Eiken, Samuel J DePalma, Adam S Helms, Rachel L Zemans, Jason R Spence, Brendon M Baker, Claudia Loebel

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Matrix stiffness induces endothelial network senescence.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Revealing the impact ofFrontiers in immunology · 2025
    Article
  5. Article
  6. Magnetoactive,Cellular and molecular bioengineering · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Donia W AhmedDepartment of Biomedical Engineering, University of Michigan, Lurie Biomedical Engineering Building, 1101 Beal Avenue, Ann Arbor, MI 48109, USA.
Madeline K EikenDepartment of Biomedical Engineering, University of Michigan, Lurie Biomedical Engineering Building, 1101 Beal Avenue, Ann Arbor, MI 48109, USA.
Samuel J DePalmaDepartment of Biomedical Engineering, University of Michigan, Lurie Biomedical Engineering Building, 1101 Beal Avenue, Ann Arbor, MI 48109, USA.
Adam S HelmsDivision of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Rachel L ZemansDepartment of Internal Medicine, Division of Pulmonary Sciences and Critical Care Medicine - Gastroenterology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA.
Jason R SpenceDepartment of Internal Medicine - Gastroenterology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA.
Brendon M BakerDepartment of Biomedical Engineering, University of Michigan, Lurie Biomedical Engineering Building, 1101 Beal Avenue, Ann Arbor, MI 48109, USA.
Claudia LoebelDepartment of Biomedical Engineering, University of Michigan, Lurie Biomedical Engineering Building, 1101 Beal Avenue, Ann Arbor, MI 48109, USA.
University of Michigan · US

Funding

Mechanisms of Alveolar Homeostasis, Injury, Regeneration, and FibrosisR35HL160770 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Rachel Lynne Zemans · 2022 to 2026
$4.3M
Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
Functional interrogation of a novel SCGB3A2+/SFTPB+ cell in the human airwayR01HL166139 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Spence · 2023 to 2026
$2.4M
Role of TGFβ/BMP Antagonism in Regeneration of the Alveolar Epithelium After Lung InjuryR01HL147920 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZEMANS, RACHEL LYNNE · 2020 to 2021
$992k
Engineered alveolar organoids to understand ECM signalingR00HL151670 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOEBEL, CLAUDIA · 2021 to 2023
$747k
NHLBI NIH HHS R00 HL151670NHLBI NIH HHS R01 HL147920NHLBI NIH HHS R01 HL166139NHLBI NIH HHS R35 HL160770NIGMS NIH HHS T32 GM145304
6 · The paper itself

Abstract

Mechanical forces provide critical biological signals to cells during healthy and aberrant organ development as well as during disease processes in adults. Within the cardiopulmonary system, mechanical forces, such as shear, compressive, and tensile forces, act across various length scales, and dysregulated forces are often a leading cause of disease initiation and progression such as in bronchopulmonary dysplasia and cardiomyopathies. Engineered

Indexed as

BioengineeringBiomaterialsBiomechanics

Identifiers

PMID38077130
PMCPMC10698280
OpenAlexW4388706510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.