Evidence map›Paper›PMID 38077060›Full record

ArticlebioRxiv : the preprint server for biology2023

Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging.

Naibedya Dutta, Joe A Gerke, Sofia F Odron, Joseph D Morris, Adam Hruby, Toni Castro Torres, Sarah J Shemtov, Jacqueline G Clarke, Michelle C Chang, Hooriya Shaghasi and 13 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Naibedya DuttaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Joe A GerkeDepartment of Natural Sciences & Mathematics, Dominican University of California, San Rafael, CA 94901, United States.
Sofia F OdronDepartment of Natural Sciences & Mathematics, Dominican University of California, San Rafael, CA 94901, United States.
Joseph D MorrisDepartment of Natural Sciences & Mathematics, Dominican University of California, San Rafael, CA 94901, United States.
Adam HrubyLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Toni Castro TorresLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Sarah J ShemtovLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Jacqueline G ClarkeDepartment of Natural Sciences & Mathematics, Dominican University of California, San Rafael, CA 94901, United States.
Michelle C ChangDepartment of Natural Sciences & Mathematics, Dominican University of California, San Rafael, CA 94901, United States.
Hooriya ShaghasiDepartment of Natural Sciences & Mathematics, Dominican University of California, San Rafael, CA 94901, United States.
Marissa N RayDepartment of Natural Sciences & Mathematics, Dominican University of California, San Rafael, CA 94901, United States.
Maxim AverbukhLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Sally HoangLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Maria OorloffLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Athena AlcalaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Matthew VegaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Hemal H MehtaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Max A ThorwaldLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Phillip CrewsDepartment of Chemistry & Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, 95064, United States.
Marc VermulstLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Gilberto GarciaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Tyler A JohnsonDepartment of Natural Sciences & Mathematics, Dominican University of California, San Rafael, CA 94901, United States.
Ryo Higuchi-SanabriaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
University of Southern California · USDominican University of California · USUniversity of California, Santa Cruz · US

Funding

Wormbase SupplementP41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 2000 to 2012
$32.0M
WormBase: a core data resource for C. elegans and other nematodesU41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KERSEY, PAUL, SCHEDL, TIM · 2013 to 2017
$20.5M
WormBase: a core data resource for C. elegans and other nematodesU24HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIM SCHEDL, PAUL Warren STERNBERG · 2018 to 2026
$18.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
USC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3M
Temporal control of mitochondrial mutagenesisR01AG075130 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Marc Vermulst · 2022 to 2026
$2.6M
Gerontology Enriching MSTEM (GEMSTEM) to Enhance Diversity in AgingR25AG076400 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AILSHIRE, JENNIFER A, CURRAN, SEAN P · 2022 to 2024
$1.1M
More than just a load control: cytoskeletal form and function during agingR00AG065200 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIGUCHI-SANABRIA, RYO · 2021 to 2023
$747k
NHGRI NIH HHS P41 HG002223NHGRI NIH HHS U24 HG002223NHGRI NIH HHS U41 HG002223NIA NIH HHS R00 AG065200NIA NIH HHS R01 AG075130NIA NIH HHS R25 AG076400NIA NIH HHS T32 AG052374NIH HHS P40 OD010440
6 · The paper itself

Abstract

Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge

Indexed as

agingcancerC. elegansmitochondriastress

Identifiers

PMID38077060
PMCPMC10705228
OpenAlexW4389068454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.