Evidence map›Paper›PMID 38077055›Full record

ArticleResearch square2023

The therapeutically actionable long non-coding RNA '

Valentin Feichtenschlager, Linan Chen, Yixuan James Zheng, Wilson Ho, Martina Sanlorenzo, Igor Vujic, Eleanor Fewings, Albert Lee, Christopher Chen, Ciara Callanan and 16 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 2 institutions in 2 countries.

Valentin FeichtenschlagerUniversity of California San Francisco.ORCID 0000-0002-3263-9285
Linan ChenUniversity of California San Francisco.
Yixuan James ZhengUniversity of California San Francisco.
Wilson HoUniversity of California San Francisco.
Martina SanlorenzoUniversity of California San Francisco.
Igor VujicDepartment of Dermatology and Venerology, Medical Institution Rudolfstiftung, Vienna, Austria.
Eleanor FewingsUniversity of California San Francisco.
Albert LeeUniversity of California San Francisco.
Christopher ChenUniversity of California San Francisco.
Ciara CallananUniversity of California San Francisco.
Kevin LinUniversity of California San Francisco.
Tiange QuUniversity of California San Francisco.
Dasha HohlovaUniversity of California San Francisco.
Marin VujicUniversity of California San Francisco.
Yeonjoo HwangUniversity of California, San Francisco.ORCID 0000-0002-3000-4710
Kevin LaiUniversity of California San Francisco.
Stephanie ChenUniversity of California San Francisco.
Thuan NguyenUniversity of California San Francisco.
Denise P MuñozUniversity of California at San Francisco.
Yoshinori KohwiUniversity of California at San Francisco.
Christian PoschSigmund Freud Private University.
Adil DaudUniversity of California at San Francisco.ORCID 0000-0002-6617-8421
Klemens RappersbergerDepartment of Dermatology, Clinic Landstrasse Vienna, Academic Teaching Hospital, Medical University Vienna, Vienna, Austria.
Terumi Kohwi-ShigematsuUniversity of California at San Francisco.
Jean-Philippe CoppéUniversity of California San Francisco.
Susana Ortiz-UrdaUniversity of California San Francisco.
University of California, San Francisco · USRudolfinerhaus Hospital · AT

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
NCI NIH HHS P30 CA082103
6 · The paper itself

Abstract

Finding effective therapeutic targets to treat NRAS-mutated melanoma remains a challenge. Long non-coding RNAs (lncRNAs) recently emerged as essential regulators of tumorigenesis. Using a discovery approach combining experimental models and unbiased computational analysis complemented by validation in patient biospecimens, we identified a nuclear-enriched lncRNA (

Indexed as

Antisense OligonucleotidesASOlncRNAMAPK-pathwaymelanomaNRAST-RECS

Identifiers

PMID38077055
PMCPMC10705697
OpenAlexW4389218945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.