Evidence map›Paper›PMID 38077053›Full record

ArticlebioRxiv : the preprint server for biology2023

Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease.

Santiago E Sanchez, Jessica Gu, Anudeep Golla, Annika Martin, William Shomali, Dirk Hockemeyer, Sharon A Savage, Steven E Artandi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Santiago E SanchezStanford Cancer Institute, Stanford University School of Medicine; Stanford, CA, USA.ORCID 0000-0001-8349-0620
Jessica GuStanford Cancer Institute, Stanford University School of Medicine; Stanford, CA, USA.
Anudeep GollaStanford Cancer Institute, Stanford University School of Medicine; Stanford, CA, USA.
Annika MartinDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA.
William ShomaliDepartment of Medicine, Stanford University School of Medicine; Stanford, CA, USA.
Dirk HockemeyerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA.
Sharon A SavageDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Steven E ArtandiStanford Cancer Institute, Stanford University School of Medicine; Stanford, CA, USA.

Funding

REVERSING CELLULAR IMMORTALITY IN CANCERR35CA197563 · NCI · STANFORD UNIVERSITY · PI ARTANDI, STEVEN E · 2015 to 2021
$6.4M
Molecular Genetics of the Telomere Biology DisordersR01HL131744 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BERTUCH, ALISON A, HOCKEMEYER, DIRK · 2016 to 2025
$4.5M
NCI NIH HHS R35 CA197563NHLBI NIH HHS R01 HL131744
6 · The paper itself

Abstract

Telomere length is an important biomarker of organismal aging and cellular replicative potential, but existing measurement methods are limited in resolution and accuracy. Here, we deploy digital telomere measurement by nanopore sequencing to understand how distributions of human telomere length change with age and disease. We measure telomere attrition and

Indexed as

agingcancerdyskeratosis congenitagenomicslong-readnanoporeshelterintelomeraseTelomeretelomere biology disorders

Identifiers

PMID38077053
PMCPMC10705489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.