Evidence map›Paper›PMID 38077050›Full record

ArticlebioRxiv : the preprint server for biology2023

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion.

Sapir Cohen Shvefel, Joy A Pai, Yingying Cao, Lipika R Pal, Ronen Levy, Winnie Yao, Kuoyuan Cheng, Marie Zemanek, Osnat Bartok, Chen Weller and 16 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 4 institutions in 2 countries.

Sapir Cohen ShvefelDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Joy A PaiDepartment of Pathology, Stanford University, Stanford, CA, USA.
Yingying CaoCancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Lipika R PalCancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Ronen LevyDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Winnie YaoDepartment of Pathology, Stanford University, Stanford, CA, USA.
Kuoyuan ChengCancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Marie ZemanekDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Osnat BartokDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Chen WellerDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Yajie YinDepartment of Pathology, Stanford University, Stanford, CA, USA.
Peter P DuDepartment of Pathology, Stanford University, Stanford, CA, USA.
Elizabeta YakubovichDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Irit OrrBioinformatics Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
Shifra Ben-DorBioinformatics Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-9604-1939
Roni OrenDepartment of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
Liat Fellus-AlyagorDepartment of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
Ofra GolaniDepartment of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
Inna GoliandDepartment of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
Dean RanmarDepartment of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
Ilya SavchenkoDepartment of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
Nadav KetrarouDepartment of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.
Alejandro A SchäfferCancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Eytan RuppinCancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Ansuman T SatpathyDepartment of Pathology, Stanford University, Stanford, CA, USA.
Yardena SamuelsDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Weizmann Institute of Science · ILNational Cancer Institute · USStanford University · USGladstone Institutes · US

Funding

MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
NIAID NIH HHS T32 AI007290
6 · The paper itself

Abstract

Decreased intra-tumor heterogeneity (ITH) correlates with increased patient survival and immunotherapy response. However, even highly homogenous tumors may display variability in their aggressiveness, and how immunologic-factors impinge on their aggressiveness remains understudied. Here we studied the mechanisms responsible for the immune-escape of murine tumors with low ITH. We compared the temporal growth of homogeneous, genetically-similar single-cell clones that are rejected vs. those that are not-rejected after transplantation

Identifiers

PMID38077050
PMCPMC10705560
OpenAlexW4389120328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.