Evidence map›Paper›PMID 38077049›Full record

ArticlebioRxiv : the preprint server for biology2023

Motif-VI Loop Acts as a Nucleotide Valve in the West Nile Virus NS3 Helicase.

Priti Roy, Zachary Walter, Lauren Berish, Holly Ramage, Martin McCullagh

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Priti RoyDepartment of Chemistry, Oklahoma State University, Stillwater, OK, USA, 74078.ORCID 0000-0003-2298-4883
Zachary WalterDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA, 19107.
Lauren BerishDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA, 19107.
Holly RamageDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, USA, 19107.ORCID 0000-0002-0390-6786
Martin McCullaghDepartment of Chemistry, Oklahoma State University, Stillwater, OK, USA, 74078.ORCID 0000-0002-8603-4388
Thomas Jefferson University · USOklahoma State University · US

Funding

Defining the Translocation Mechanisms of SARS-CoV-2 nsp13 Helicase to Aid in Antiviral DevelopmentR01AI166050 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI MCCULLAGH, MARTIN · 2021 to 2025
$2.2M
Defining the Role of West Nile Virus-Host Protein Interactions in Evading Antiviral ImmunityR01AI143850 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI RAMAGE, HOLLY · 2019 to 2023
$2.2M
Training Grant in Cellular, Biochemical and Molecular SciencesT32GM144302 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI DIANE E MERRY, PHILIP B WEDEGAERTNER · 2022 to 2026
$2.0M
NIAID NIH HHS R01 AI143850NIAID NIH HHS R01 AI166050NIGMS NIH HHS T32 GM144302
6 · The paper itself

Abstract

The flavivirus NS3 helicase (NS3h), a highly conserved protein, plays a pivotal role in virus replication and thus represents a potential drug target for flavivirus pathogenesis. NS3h utilizes nucleotide triphosphate, such as ATP, for hydrolysis energy (ATPase) to translocate on single-stranded nucleic acids, which is an important step in the unwinding of double-stranded nucleic acids. The intermediate states along the ATP binding and hydrolysis cycle, as well as the conformational changes between these states, represent important yet difficult-to-identify targets for potential inhibitors. We use extensive molecular dynamics simulations of apo, ATP, ADP+P

Identifiers

PMID38077049
PMCPMC10705498
OpenAlexW4389207485

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.