Evidence map›Paper›PMID 38077047›Full record

ArticlebioRxiv : the preprint server for biology2023

Negative feedback control of hunger circuits by the taste of food.

Tara J Aitken, Truong Ly, Sarah Shehata, Nilla Sivakumar, Naymalis La Santa Medina, Lindsay A Gray, Naz Dundar, Chris Barnes, Zachary A Knight

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tara J AitkenNeuroscience Graduate Program, University of California, San Francisco; San Francisco, CA 94158, USA.
Truong LyNeuroscience Graduate Program, University of California, San Francisco; San Francisco, CA 94158, USA.
Sarah ShehataHoward Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA.
Nilla SivakumarHoward Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA.
Naymalis La Santa MedinaHoward Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA.
Lindsay A GrayHoward Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA.
Naz DundarNeuroscience Graduate Program, University of California, San Francisco; San Francisco, CA 94158, USA.
Chris BarnesHoward Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA.
Zachary A KnightDepartment of Physiology, University of California, San Francisco; San Francisco, CA 94158, USA.
Howard Hughes Medical Institute · USUniversity of California, San Francisco · US

Funding

Neural Dynamics Underlying FeedingR01DK106399 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Zachary A. Knight · 2015 to 2026
$4.8M
Neural mechanisms linking need to rewardRF1NS116626 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERKE, JOSHUA D, KNIGHT, ZACHARY A. · 2020 to 2020
$2.7M
Neural mechanisms linking need to rewardR01NS116626 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERKE, JOSHUA D, KNIGHT, ZACHARY A. · 2023 to 2024
$1.7M
Neural mechanisms that control the rate of ingestionR01DK138127 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Zachary A. Knight · 2024 to 2026
$1.4M
Dissecting the role of neural inputs in the regulation of AgRP neuronsF31DK125067 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AITKEN, TARA J · 2021 to 2023
$127k
NIDDK NIH HHS F31 DK125067NIDDK NIH HHS R01 DK106399NIDDK NIH HHS R01 DK138127NINDS NIH HHS R01 NS116626NINDS NIH HHS RF1 NS116626
6 · The paper itself

Abstract

The rewarding taste of food is critical for motivating animals to eat, but whether taste has a parallel function in promoting meal termination is not well understood. Here we show that hunger-promoting AgRP neurons are rapidly inhibited during each bout of ingestion by a signal linked to the taste of food. Blocking these transient dips in activity via closed-loop optogenetic stimulation increases food intake by selectively delaying the onset of satiety. We show that upstream leptin receptor-expressing neurons in the dorsomedial hypothalamus (DMH

Indexed as

AgRParcuate nucleusDMHfeedinghungerhypothalamusleptin receptortaste

Identifiers

PMID38077047
PMCPMC10705440
OpenAlexW4389288995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.