Evidence map›Paper›PMID 38077018›Full record

ArticleResearch square2023

Improved Quantification of MicroPET/CT Imaging Using CT-derived Scaling Factors.

Ayon Nandi, Masayoshi Nakano, James Robert Brašić, Zabecca S Brinson, Kelly Kitzmiller, Anil Mathur, Mona Mohamed, Joshua Roberts, Dean F Wong, Hiroto Kuwabara

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Ayon NandiJohns Hopkins School of Medicine: The Johns Hopkins University School of Medicine.ORCID 0000-0002-1549-8900
Masayoshi NakanoJanssen Pharmaceutical KK: Janssen Pharma Kabushiki Kaisha.
James Robert BrašićNew York University Grossman School of Medicine.
Zabecca S BrinsonThe University of Texas Southwestern Medical Center.
Kelly KitzmillerUniversity of Maryland Medical Center.
Anil MathurJohns Hopkins School of Medicine: The Johns Hopkins University School of Medicine.
Mona MohamedAin Shams University.
Joshua RobertsJohns Hopkins School of Medicine: The Johns Hopkins University School of Medicine.
Dean F WongWashington University in St Louis School of Medicine Mallinckrodt Institute of Radiology.
Hiroto KuwabaraJohns Hopkins School of Medicine: The Johns Hopkins University School of Medicine.
Johns Hopkins University · USAin Shams University · EGJanssen (Belgium) · BENew York University · USThe University of Texas Southwestern Medical Center · USUniversity of Maryland, Baltimore · US

Funding

Combined mGluR5 PET and fMRI imaging of Sex Differences during Cocaine WithdrawalR01DA042094 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MCCAUL, MARY E, WAND, GARY S · 2017 to 2022
$3.5M
HOMOCYSTEINE, A CANDIDATE PERIPHERAL BIOMARKER FOR CEREBRAL mGluR5 ACTIVITY IN COMORBID ALCOHOL- AND TOBACCO USE DISORDERR01AA023483 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI MCCAUL, MARY E, WONG, DEAN FOSTER · 2015 to 2019
$3.5M
NIAAA NIH HHS R01 AA023483NIDA NIH HHS R01 DA042094
6 · The paper itself

Abstract

Purpose: Combined micro-PET/CT scanners are widely employed to investigate models of brain disorders in rodents using PET-based coregistration. We examined if CT-based coregistration could improve estimates of brain dimensions and consequently estimates of nondisplaceable binding potential (BP Procedures: PET and CT scans were acquired on 5 female and 5 male CD-1 mice with PET and CT scans were acquired on 5 female and 5 male CD-1 mice with 3-[ Results: The PET-based approaches showed various degrees of underestimations of scaling factors in the posterior-anterior-direction compared to PTCT, which resulted in negatively proportional overestimation of radioactivity in the cerebellum (reference region) up to 20%, and proportional, more prominent underestimation of BP Conclusions: The results indicated that conventional PET-based coregistration approaches could yield biased estimates of BP

Identifiers

PMID38077018
PMCPMC10705595
OpenAlexW4389164540

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.