ArticlebioRxiv : the preprint server for biology2023
The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes.
Amanda K Riley, Michael Grant, Aidan Snell, Athea Vichas, Sitapriya Moorthi, Anatoly Urisman, Pau Castel, Lixin Wan, Alice H Berger
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors at 5 institutions in 1 country.
Michael GrantDepartment of Molecular Oncology, Molecular Medicine Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Aidan SnellDepartment of Molecular Oncology, Molecular Medicine Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Athea VichasHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sitapriya MoorthiHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Pau CastelDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-4972-4347 Lixin WanDepartment of Molecular Oncology, Molecular Medicine Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Alice H BergerHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Moffitt Cancer Center · USFred Hutch Cancer Center · USUniversity of Washington · USNew York University · USUniversity of California, San Francisco · US
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4MUnderstanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancerR37CA252050 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Alice Berger · 2021 to 2026
$3.1MCharacterizing oncogenic function of ITCH in melanomaR01CA255398 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Lixin Wan · 2021 to 2026
$1.8MElucidating how a USP9X-COP1 axis regulates RIT1 protein abundance and reveals druggable targets in lung adenocarcinomaF31CA271637 · NCI · FRED HUTCHINSON CANCER CENTER · PI RILEY, AMANDA · 2022 to 2023
$74kNCI NIH HHS F31 CA271637NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA255398NCI NIH HHS R37 CA252050
6 · The paper itselfAbstract
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Identifiers
PMID38077017
PMCPMC10705424
OpenAlexW4389231459
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