Evidence map›Paper›PMID 38076995›Full record

ArticlebioRxiv : the preprint server for biology2023

The Myc-Like Mlx Network Impacts Aging and Metabolism.

Huabo Wang, Taylor Stevens, Jie Lu, Alexander Roberts, Clinton Van't Land, Radhika Muzumdar, Zhenwei Gong, Jerry Vockley, Edward V Prochownik

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Huabo WangDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh.ORCID 0000-0003-2551-3243
Taylor StevensDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh.
Jie LuDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh.
Alexander RobertsDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh.
Clinton Van't LandDivision of Medical Genetics, UPMC Children's Hospital of Pittsburgh.
Radhika MuzumdarDivision of Endocrinology, UPMC Children's Hospital of Pittsburgh.
Zhenwei GongDivision of Endocrinology, UPMC Children's Hospital of Pittsburgh.
Jerry VockleyDivision of Medical Genetics, UPMC Children's Hospital of Pittsburgh.
Edward V ProchownikDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh.
Children's Hospital of Pittsburgh · USUPMC Hillman Cancer Center · US

Funding

Control of Metabolism and Energy-Sensing Pathways by c-MycR01CA174713 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PROCHOWNIK, EDWARD VICTOR · 2014 to 2018
$1.6M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
NCI NIH HHS R01 CA174713NIH HHS S10 OD028483
6 · The paper itself

Abstract

The "Mlx" and "Myc" Networks share many common gene targets. Just as Myc's activity depends upon its heterodimerization with Max, the Mlx Network requires that the Max-like factor Mlx associate with the Myc-like factors MondoA or ChREBP. We show here that body-wide

Indexed as

Cancer metabolismDNA damageMitochondriaMycreactive oxygen speciesTCA cycletelomeresWarburg effect

Identifiers

PMID38076995
PMCPMC10705233
OpenAlexW4389040643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.