Evidence map›Paper›PMID 38076983›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent.

Li Li, Irshad Hajam, Jean S McGee, Zhengkuan Tang, Ye Zhang, Nikil Badey, Esther Mintzer, Zhenrui Zhang, George Y Liu, George M Church and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Li LiDepartment of Genetics, Harvard Medical School, Boston, USA.ORCID 0009-0002-5937-9679
Irshad HajamDepartment of Pediatrics, School of Medicine, UC San Diego, San Diego, USA.ORCID 0000-0003-4010-1845
Jean S McGeeDepartment of Dermatology, Beth Israel Deaconess Medical Center, Boston, USA.ORCID 0000-0001-8490-0169
Zhengkuan TangDepartment of Genetics, Harvard Medical School, Boston, USA.ORCID 0009-0006-2922-4210
Ye ZhangSchool of Public Health, Harvard University, Boston, USA.
Nikil BadeyDepartment of Genetics, Harvard Medical School, Boston, USA.ORCID 0009-0001-3917-0520
Esther MintzerDepartment of Genetics, Harvard Medical School, Boston, USA.ORCID 0000-0003-2710-0856
Zhenrui ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.ORCID 0000-0003-0563-9148
George Y LiuDepartment of Pediatrics, School of Medicine, UC San Diego, San Diego, USA.ORCID 0000-0003-0759-0587
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, USA.ORCID 0000-0001-6232-9969
Yu WangDepartment of Genetics, Harvard Medical School, Boston, USA.ORCID 0000-0001-9764-0546
Harvard University · USUniversity of California San Diego · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · US

Funding

Pathogenic and protective roles of strain-specific P. acnes hyaluronidases in acneR01AI141401 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI LIU, GEORGE Y, MURALI, RAMACHANDRAN · 2019 to 2023
$2.7M
NIAID NIH HHS R01 AI141401
6 · The paper itself

Abstract

Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these conditions do exhibit certain resemblances, they also demonstrate distinct underlying pathophysiological mechanisms and treatment modalities. Delving into both the molecular parallels and disparities among these three disorders can yield invaluable insights for refined diagnostics, effective management, and targeted therapeutic interventions. In this report, we present a comparative analysis of transcriptomic data across these three diseases, elucidating differentially expressed genes and enriched pathways specific to each ailment, as well as those shared among them. We also identified high dose dietary zinc as a potential therapeutic agent and validated its efficacy in an acne mouse model.

Identifiers

PMID38076983
PMCPMC10705630
OpenAlexW4389126305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.