Evidence map›Paper›PMID 38076977›Full record

ArticlebioRxiv : the preprint server for biology2023

Testing SIPA1L2 as a modifier of CMT1A using mouse models.

George C Murray, Timothy J Hines, Abigail L D Tadenev, Isaac Xu, Stephan Züchner, Robert W Burgess

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

George C MurrayThe Jackson Laboratory, Bar Harbor, ME 04609.
Timothy J HinesThe Jackson Laboratory, Bar Harbor, ME 04609.
Abigail L D TadenevThe Jackson Laboratory, Bar Harbor, ME 04609.
Isaac XuDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Stephan ZüchnerDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Robert W BurgessThe Jackson Laboratory, Bar Harbor, ME 04609.
Jackson Laboratory · USUniversity of Miami · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
The Genetics of the Neuromuscular Junction: Mechanisms and Disease ModelsR37NS054154 · NINDS · JACKSON LABORATORY · PI Robert W. Burgess · 2020 to 2026
$5.9M
Transdisciplinary Predoctoral Training in Biomedical Science and EngineeringT32GM132006 · NIGMS · UNIVERSITY OF MAINE ORONO · PI GREGORY A. COX, Clarissa A Henry · 2019 to 2026
$2.0M
A Resource for Mouse Models of Peripheral NeuropathyR24NS098523 · NINDS · JACKSON LABORATORY · PI BOGDANIK, LAURENT P, BURGESS, ROBERT W. · 2016 to 2019
$1.2M
Investigating SIPA1L2 as a Modifier Gene and Therapeutic Target for Charcot-Marie-Tooth Type 1AR21NS116936 · NINDS · JACKSON LABORATORY · PI BURGESS, ROBERT W. · 2020 to 2020
$468k
NCI NIH HHS P30 CA034196NIGMS NIH HHS T32 GM132006NINDS NIH HHS R21 NS116936NINDS NIH HHS R24 NS098523NINDS NIH HHS R37 NS054154
6 · The paper itself

Abstract

Charcot-Marie-Tooth 1A is a demyelinating peripheral neuropathy caused by the duplication of peripheral myelin protein 22 (

Identifiers

PMID38076977
PMCPMC10705403
OpenAlexW4389259529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.