Evidence map›Paper›PMID 38076957›Full record

ArticlebioRxiv : the preprint server for biology2023

Epithelial organoid supports resident memory CD8 T cell differentiation.

Max R Ulibarri, Ying Lin, Julian R Ramprashad, Geongoo Han, Mohammad H Hasan, Farha J Mithila, Chaoyu Ma, Smita Gopinath, Nu Zhang, J Justin Milner and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Max R UlibarriDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912.
Ying LinDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912.
Julian R RamprashadDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912.
Geongoo HanDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912.
Mohammad H HasanDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912.
Farha J MithilaDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912.
Chaoyu MaDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center, San Antonio, TX, 78229.
Smita GopinathDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Cambridge, MA, 02115.
Nu ZhangDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center, San Antonio, TX, 78229.
J Justin MilnerDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, 27599.
Lalit K BeuraDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912.
Brown University · USThe University of Texas Health Science Center at San Antonio · USHarvard University · USUniversity of North Carolina at Chapel Hill · US

Funding

The role of Sirtuins in neurodegenerative diseaseP20GM109035 · NIGMS · BROWN UNIVERSITY · PI LIU, YAJUN · 2016 to 2025
$22.6M
Brown Respiratory Research Training ProgramT32HL134625 · NHLBI · BROWN UNIVERSITY · PI Elizabeth O Harrington, Sharon Irene Smith Rounds · 2017 to 2026
$5.1M
Predoctoral Training in Molecular, Cellular, and Biochemical SciencesT32GM136566 · NIGMS · BROWN UNIVERSITY · PI Mark Aikens Johnson, Erica Nicole Larschan · 2020 to 2026
$3.1M
NHLBI NIH HHS T32 HL134625NIGMS NIH HHS P20 GM109035NIGMS NIH HHS T32 GM136566
6 · The paper itself

Abstract

Resident Memory T cells (TRM) play a vital role in regional immune defense in barrier organs. Although laboratory rodents have been extensively used to study fundamental TRM biology, poor isolation efficiency, sampling bias and low cell survival rates have limited our ability to conduct TRM-focused high-throughput assays. Here, we engineered a murine vaginal epithelial organoid (VEO)-CD8 T cell co-culture system that supports CD8 TRM differentiation

Indexed as

CD8 resident memory T cellsin vitro differentiationVaginal epithelial organoids

Identifiers

PMID38076957
PMCPMC10705482
OpenAlexW4389243688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.