Evidence map›Paper›PMID 38076938›Full record

ArticlebioRxiv : the preprint server for biology2023

Normative Modeling of Brain Morphometry Across the Lifespan Using CentileBrain: Algorithm Benchmarking and Model Optimization.

Ruiyang Ge, Yuetong Yu, Yi Xuan Qi, Yunan Vera Fan, Shiyu Chen, Chuntong Gao, Shalaila S Haas, Amirhossein Modabbernia, Faye New, Ingrid Agartz and 102 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

112 authors.

Ruiyang GeDjavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Yuetong YuDjavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Yi Xuan QiDjavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Yunan Vera FanDjavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Shiyu ChenDjavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Chuntong GaoDjavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Shalaila S HaasDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Amirhossein ModabberniaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Faye NewDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ingrid AgartzNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Philip AshersonInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Center, King's College London, London, UK.
Rosa Ayesa-ArriolaDepartment of Psychiatry, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain.
Nerisa BanajLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany.
Sarah BaumeisterDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany.
Alessandro BertolinoDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Stefan BorgwardtTranslational Psychiatry Unit, Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.
Josiane BourqueDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany.
Alan BreierDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Henry BrodatyCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia.
Rachel M BrouwerDepartment of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Randy BucknerDepartment of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Dara M CannonClinical Neuroimaging Laboratory, National University of Ireland Galway, Galway, Ireland.
Xavier CaserasMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Simon CervenkaCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Patricia J ConrodDepartment of Psychiatry and Addiction, Université de Montréal, CHU Ste Justine, Montréal, Canada.
Benedicto Crespo-FacorroUniversity Hospital Virgen del Rocio, Seville, Spain; Department of Psychiatry, University of Seville, Institute of Biomedicine of Seville (IBIS), Seville, Spain.
Fabrice CrivelloInstitut des Maladies Neurodégénératives, Université de Bordeaux, Bordeaux, France.
Eveline A CroneDepartment of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Liewe de HaanDepartment of Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands.
Greig I de ZubicaraySchool of Psychology & Counselling, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
Annabella Di GiorgioLaboratory of Biological Psychiatry, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Susanne ErkDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Barbara FrankeDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Thomas FrodlUniversity Clinics and Clinics for Psychiatry, Psychotherapy and Psychosomatic Medicine, RWTH Aachen University, Aachen, Germany.
David C GlahnDepartment of Psychiatry, Tommy Fuss Center for Neuropsychiatric Disease Research Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Dominik GrotegerdDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Patricia GrunerDepartment of Psychiatry, Yale University, New Haven, Connecticut, USA.
Raquel E GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ruben C GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ben J HarrisonMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Australia.
Sean N HattonCenter for Multimodal Imaging and Genetics, University of California San Diego, La jolla, California, USA.
Ian HickieBrain and Mind Centre, University of Sydney, Sydney, Australia.
Fleur M HowellsNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Hilleke E Hulshoff PolDepartment of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Chaim HuyserDepartment of Child and Adolescent Psychiatry, Academic Medical Centre/De Bascule, Amsterdam, The Netherlands.
Terry L JerniganCenter for Human Development, Departments of Cognitive Science, Psychiatry, and Radiology, University of California, San Diego, USA.
Jiyang JiangCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia.
John A JoskaDepartment of Neuropsychiatry, University of Cape Town, Cape Town, South Africa.
René S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew J KalninDepartment of Radiology, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Nicole A KochanCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia.
Sanne KoopsDepartment of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Jonna KuntsiInstitute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Center, King's College London, London, UK.
Jim LagopoulosSunshine Coast Mind and Neuroscience - Thompson Institute, University of the Sunshine Coast, Queensland, Australia.
Luisa LazaroDepartment of Child and Adolescent Psychiatry and Psychology, Hospital Clínic Barcelona, Barcelona, Spain.
Irina S LebedevaMental Health Research Center, Moscow, Russia.
Christine LochnerSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Nicholas G MartinQueensland Institute of Medical Research, Berghofer Medical Research Institute, Brisbane, Australia.
Bernard MazoyerInstitut des Maladies Neurodégénératives, Université de Bordeaux, Bordeaux, France.
Brenna C McDonaldDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Colm McDonaldCentre for Neuroimaging & Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.
Katie L McMahonSchool of Clinical Sciences, Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Australia.
Tomohiro NakaoDepartment of Neuropsychiatry, Kyushu University, Fukuoka, Japan.
Lars NybergDepartment of Radiation Sciences, Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.
Fabrizio PirasLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Maria J PortellaMental Health Research Networking Center (CIBERSAM), Madrid, Spain.
Jiang QiuKey Laboratory of Cognition and Personality, Southwest University, Ministry of Education, Chongqing, PR China.
Joshua L RoffmanDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Perminder S SachdevCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia.
Nicole SanfordDjavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Theodore D SatterthwaiteDepartment of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Gunter SchumannCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology, and Neuroscience, Social, Genetic & Developmental Psychiatry Centre, King's College London, London, UK; Institute for Science and Technology of Brain-inspired Intelligence, Fudan University, Shanghai, PR China; Centre for Population Neuroscience and Stratified Medicine (PONS), Charite Mental Health, Department of Psychiatry and Psychotherapy, CCM, Charite Universitätsmedizin Berlin, Berlin, Germany.
Carl M SellgrenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Kang SimInstitute of Mental Health, Singapore.
Jordan W SmollerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jair SoaresUniversity of Texas Health Harris County Psychiatric Center, Houston, Texas, USA.
Iris E SommerDepartment of Biomedical Sciences of Cells and Systems, Rijksuniversiteit Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Gianfranco SpallettaLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Dan J SteinSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Christian K TamnesNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Sophia I ThomopolousGenetics Center, Stevens Institute for Neuroimaging and Informatics, Keck USC School of Medicine, Marina del Rey, California, USA.
Alexander S TomyshevMental Health Research Center, Moscow, Russia.
Diana Tordesillas-GutiérrezDepartment of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain; Advanced Computing and e-Science, Instituto de Física de Cantabria (UC-CSIC), Santander, Spain.
Julian N TrollorCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia.
Dennis van 't EntDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Odile A van den HeuvelDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Theo Gm van ErpDepartment of Psychiatry and Human Behavior, University of California, Irvine, California, USA.
Neeltje Em van HarenDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Daniela VecchioLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Dick J VeltmanDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Henrik WalterDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Yang WangDepartment of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Bernd WeberInstitute for Experimental Epileptology and Cognition Research, University of Bonn Germany, Bonn, Germany; University Hospital Bonn, Bonn, Germany.
Dongtao WeiKey Laboratory of Cognition and Personality, Southwest University, Ministry of Education, Chongqing, PR China.
Wei WenCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia.
Lars T WestlyeDepartment of Psychology, University of Oslo, Oslo, Norway.
Lara M WierengaInstitute of Psychology, Leiden University, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
Steven Cr WilliamsDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Sarah MedlandQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Mon-Ju WuDepartment of Psychiatry and Behavioral Science, University of Texas Health Science Center, Houston, Texas, USA.
Kevin YuDjavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Neda JahanshadGenetics Center, Stevens Institute for Neuroimaging and Informatics, Keck USC School of Medicine, Marina del Rey, California, USA.
Paul M ThompsonGenetics Center, Stevens Institute for Neuroimaging and Informatics, Keck USC School of Medicine, Marina del Rey, California, USA.
Sophia FrangouDjavad Mowafagian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
FUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
INDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0M
BIO-INFORMATICS RESEARCH NETWORK COORDINATING CENTER (BIRN-CC)U24RR025736 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL · 2009 to 2011
$15.0M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
NEUROBEHAVIORAL STUDY OF SCHIZOPHRENIAR01MH042191 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 1987 to 2018
$7.1M
NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR004419NCI NIH HHS R01 CA101318NCRR NIH HHS U24 RR021992NCRR NIH HHS U24 RR025736NCRR NIH HHS UL1 RR025761NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG067420NIBIB NIH HHS U54 EB020403NICHD NIH HHS P50 HD105351NICHD NIH HHS R01 HD050735NIDA NIH HHS RC2 DA029475NIDA NIH HHS U24 DA041147NIMH NIH HHS R01 MH042191NIMH NIH HHS R01 MH090553NIMH NIH HHS R01 MH104284NIMH NIH HHS R01 MH113619NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117014NIMH NIH HHS T32 MH122394
6 · The paper itself

Abstract

We present an empirically benchmarked framework for sex-specific normative modeling of brain morphometry that can inform about the biological and behavioral significance of deviations from typical age-related neuroanatomical changes and support future study designs. This framework was developed using regional morphometric data from 37,407 healthy individuals (53% female; aged 3-90 years) following a comparative evaluation of eight algorithms and multiple covariate combinations pertaining to image acquisition and quality, parcellation software versions, global neuroimaging measures, and longitudinal stability. The Multivariate Factorial Polynomial Regression (MFPR) emerged as the preferred algorithm optimized using nonlinear polynomials for age and linear effects of global measures as covariates. The MFPR models showed excellent accuracy across the lifespan and within distinct age-bins, and longitudinal stability over a 2-year period. The performance of all MFPR models plateaued at sample sizes exceeding 3,000 study participants. The model and scripts described here are freely available through CentileBrain (https://centilebrain.org/).

Identifiers

PMID38076938
PMCPMC10705253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.