Evidence map›Paper›PMID 38076935›Full record

ArticlebioRxiv : the preprint server for biology2023

Differential CpG methylation at

Vanessa Yu, Fiona Yong, Angellica Marta, Sanjay Khadayate, Adrien Osakwe, Supriyo Bhattacharya, Sneha S Varghese, Pauline Chabosseau, Sayed M Tabibi, Keran Chen and 26 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 7 institutions in 5 countries.

Vanessa YuDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Fiona YongDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.ORCID 0000-0003-1649-4386
Angellica MartaDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Sanjay KhadayateMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
Adrien OsakweDepartments of Medicine, Human Genetics and Quantitative Life Sciences, McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada.
Supriyo BhattacharyaDepartment of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA.
Sneha S VargheseDepartment of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA.
Pauline ChabosseauDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Sayed M TabibiDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Keran ChenDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Eleni GeorgiadouDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Nazia ParveenDepartment of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA.
Mara SuleimanDepartment of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.
Zoe StamoulisDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Lorella MarselliDepartment of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.
Carmela De LucaDepartment of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.
Marta TesiDepartment of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.
Giada OstinelliCHUM Research Center and Faculty of Medicine, University of Montréal, 900 Rue St Denis, Montréal, H2X OA9, QC, Canada.
Luis Delgadillo-SilvaCHUM Research Center and Faculty of Medicine, University of Montréal, 900 Rue St Denis, Montréal, H2X OA9, QC, Canada.
Xiwei WuDepartment of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA.
Yuki HatanakaMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
Alex MontoyaMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
James ElliottMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
Bhavik PatelMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
Nikita DemchenkoMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
Chad WhildingMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
Petra HajkovaMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
Pavel ShliahaMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
Holger KramerMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.
Yusuf AliNutrition, Metabolism and Health Programme & Centre for Microbiome Medicine, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, 308232.
Piero MarchettiDepartment of Clinical and Experimental Medicine, and AOUP Cisanello University Hospital, University of Pisa, Pisa 56126, Italy.ORCID 0000-0003-4907-0635
Robert SladekDepartments of Medicine, Human Genetics and Quantitative Life Sciences, McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada.
Sangeeta DhawanDepartment of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA.ORCID 0000-0002-1562-7899
Dominic J WithersMRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0NN, UK.ORCID 0000-0002-8009-7521
Guy A RutterDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.ORCID 0000-0001-6360-0343
Steven J MillershipDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.ORCID 0000-0001-6947-7059
Imperial College London · GBUniversity of Pisa · ITCity of Hope · USNanyang Technological University · SGCity Of Hope National Medical Center · USMcGill University and Génome Québec Innovation Centre · CAUniversité de Montréal · CA

Funding

Control of insulin secretion by mitochondrial fusionR01DK135268 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brett A Kaufman, Scott Soleimanpour · 2023 to 2026
$2.4M
Regulation of beta-cell homeostasis by DNA methylation and hydroxymethylation.R01DK120523 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI DHAWAN, SANGEETA · 2019 to 2023
$2.2M
Medical Research Council MC_U120097114Medical Research Council MR/R010676/1Medical Research Council MR/R022259/1NIDDK NIH HHS R01 DK120523NIDDK NIH HHS R01 DK135268Wellcome Trust
6 · The paper itself

Abstract

Aims/hypothesis: Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly-connected 'hub' cells, important for the propagation of intercellular Ca Methods: Single cell RNA-seq datasets were examined using Seurat 4.0 and ClusterProfiler running under R. Transgenic mice expressing eGFP under the control of the Results: Conclusions/interpretation: These findings demonstrate that differential DNA methylation at

Indexed as

Beta cell developmentCa2+connectivityCpG methylationheterogeneityidentityimprinted genesinsulinisletneuronatintype 2 diabetes

Identifiers

PMID38076935
PMCPMC10705251
OpenAlexW4319265313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.