Evidence map›Paper›PMID 38076931›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events.

Henrike O Heyne, Fanny-Dhelia Pajuste, Julian Wanner, Jennifer I Daniel Onwuchekwa, Reedik Mägi, Aarno Palotie, FinnGen, Estonian Biobank research team, Reetta Kälviainen, Mark J Daly

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Henrike O HeyneHasso Plattner Institute for Digital Engineering, University of Potsdam, Germany.ORCID 0000-0001-9893-3850
Fanny-Dhelia PajusteEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Julian WannerHasso Plattner Institute for Digital Engineering, University of Potsdam, Germany.ORCID 0000-0002-1487-7909
Jennifer I Daniel OnwuchekwaHasso Plattner Institute for Digital Engineering, University of Potsdam, Germany.
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Aarno PalotieFinnish Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.
FinnGen, Estonian Biobank research team
Reetta KälviainenKuopio Epilepsy Center, Neurocenter, Kuopio University Hospital, Member of ERN EpiCARE, Kuopio, Finland.
Mark J DalyFinnish Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0949-8752
Broad Institute · USUniversity of Tartu · EEHasso Plattner Institute · DEUniversity of Eastern Finland · FIUniversity of Helsinki · FI

Funding

Shared Genetics and Risk Factors Between Epilepsy and Psychiatric DiseaseR01NS106104 · NINDS · YALE UNIVERSITY · PI BRENNAND, KRISTEN JENNIFER · 2019 to 2023
$2.5M
NINDS NIH HHS R01 NS106104
6 · The paper itself

Abstract

A diagnosis of epilepsy has significant consequences for an individual but is often challenging in clinical practice. Novel biomarkers are thus greatly needed. Here, we investigated how common genetic factors (epilepsy polygenic risk scores, [PRSs]) influence epilepsy risk in detailed longitudinal electronic health records (EHRs) of > 360k Finns spanning up to 50 years of individuals' lifetimes. Individuals with a high genetic generalized epilepsy PRS (PRS

Identifiers

PMID38076931
PMCPMC10705659
OpenAlexW4389042131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.