Evidence map›Paper›PMID 38076920›Full record

ArticleResearch square2023

"MrgprA3 neurons selectively control myeloid-derived cytokines for IL-17 dependent cutaneous immunity".

Juan M Inclan-Rico, Camila M Napuri, Cailu Lin, Li-Yin Hung, Annabel A Ferguson, Qinxue Wu, Christopher F Pastore, Adriana Stephenson, Ulrich M Femoe, Heather L Rossi and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Juan M Inclan-RicoDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1134-9139
Camila M NapuriDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Cailu LinMonell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Li-Yin HungDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Annabel A FergusonDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Qinxue WuDepartment of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Christopher F PastoreDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1002-6138
Adriana StephensonDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ulrich M FemoeDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Heather L RossiDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Danielle R ReedMonell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Wenqin LuoDepartment of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ishmail Abdus-SaboorDepartment of Biological Sciences, Zuckerman Mind, Brain, Behavior Institute, Columbia University, New York, New York, USA.
De'Broski R HerbertDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-2449-5365
California University of Pennsylvania · USMonell Chemical Senses Center · USCalifornia Institute for Regenerative Medicine · USMIND Research Institute · US

Funding

PARASITOLOGY: MODERN APPROACHEST32AI007532 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 1998 to 2022
$5.0M
Perforin 2 controls unconventional cytokine release from mucosal APCU01AI163062 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2025
$2.4M
Physiological roles of schistosome TRP ion channels with atypical pharmacologyR01AI123173 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2017 to 2021
$2.0M
Myeloid derived IL-33 controls Treg responses during parasite infectionR01AI164715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2024
$1.6M
NIAID NIH HHS HHSN272201700014CNIAID NIH HHS R01 AI123173NIAID NIH HHS R01 AI164715NIAID NIH HHS T32 AI007532NIAID NIH HHS U01 AI163062
6 · The paper itself

Abstract

Skin employs interdependent cellular networks to facilitate barrier integrity and host immunity through ill-defined mechanisms. This study demonstrates that manipulation of itch-sensing neurons bearing the Mas-related G protein-coupled receptor A3 (MrgprA3) drives IL-17+ γδ T cell expansion, epidermal thickening, and resistance to the human pathogen

Indexed as

helminthsIL-33keratinizationmacrophagesMrgprA3type 17 responses

Identifiers

PMID38076920
PMCPMC10705600
OpenAlexW4389153562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.