ArticleResearch square2023
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.
Lynn A C Devilée, Jessica M Miller, Janice D Reid, Abou Bakr M Salama, Qinghui Ou, Madiha Jamal, Yibing Nong, Douglas Andres, Jonathan Satin, Tamer M A Mohamed and 2 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors at 6 institutions in 4 countries.
Lynn A C DeviléeQIMR Berghofer Medical Research Institute, Cardiac Bioengineering Laboratory, Brisbane, Queensland, Australia.ORCID 0000-0002-6176-4392 Jessica M MillerInstitute of Molecular Cardiology, Department of Medicine, University of Louisville, KY, U.S.A.
Janice D ReidQIMR Berghofer Medical Research Institute, Cardiac Bioengineering Laboratory, Brisbane, Queensland, Australia.
Abou Bakr M SalamaInstitute of Molecular Cardiology, Department of Medicine, University of Louisville, KY, U.S.A.ORCID 0000-0002-2241-3792 Qinghui OuInstitute of Molecular Cardiology, Department of Medicine, University of Louisville, KY, U.S.A.
Madiha JamalInstitute of Molecular Cardiology, Department of Medicine, University of Louisville, KY, U.S.A.
Yibing NongCenter for Cardiometabolic Science, Christina Lee Brown Envirome Institute, Department of Medicine, University of Louisville, Louisville, KY, U.S.A.
Douglas AndresDepartment of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, U.S.A.
Jonathan SatinDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY, U.S.A.
Tamer M A MohamedInstitute of Molecular Cardiology, Department of Medicine, University of Louisville, KY, U.S.A.
James E HudsonQIMR Berghofer Medical Research Institute, Cardiac Bioengineering Laboratory, Brisbane, Queensland, Australia.ORCID 0000-0003-0832-9356 Riham R E AbouleisaInstitute of Molecular Cardiology, Department of Medicine, University of Louisville, KY, U.S.A.ORCID 0000-0001-8883-068X Baylor College of Medicine · USQIMR Berghofer Medical Research Institute · AUUniversity of Louisville Hospital · USAlfaisal University · SABioengineering Center · RUUniversity of Kentucky · US
Funding
TBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI JONES, STEVEN P · 2018 to 2022
$6.3MInduction of Cardiomyocyte Proliferation via Transient Expression of Cell Cycle Factors as a Promising Therapy for Heart FailureR01HL147921 · NHLBI · UNIVERSITY OF LOUISVILLE · PI Tamer M A Mohamed, Jonathan Satin · 2020 to 2026
$5.3MDefining the major signaling mechanism which controls spontaneous cardiomyocyte proliferation in the Neonatal StageR01HL178610 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Tamer M A Mohamed · 2025 to 2026
$1.5MTriple Gene Therapy for Ischemic Heart FailureR61HL177472 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MOHAMED, TAMER M A, ROSENGART, TODD K · 2025 to 2025
$560kDeciphering the Relationship Between Cardiomyocyte Metabolic Configuration and Cell Cycle Re-entryF32HL149140 · NHLBI · UNIVERSITY OF LOUISVILLE · PI ABOULEISA, RIHAM RAAFAT ELGHARIB · 2020 to 2023
$243kNHLBI NIH HHS F32 HL149140NHLBI NIH HHS R01 HL147921NHLBI NIH HHS R01 HL178610NHLBI NIH HHS R61 HL177472NIGMS NIH HHS P30 GM127607
6 · The paper itselfAbstract
Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity, which leads to progressive heart failure. Calcium (Ca
Indexed as
calcineurinCalciumCardiomyocyte proliferationCell cycleLTCCRRAD
Identifiers
PMID38076903
PMCPMC10705701
OpenAlexW4389175383
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