Evidence map›Paper›PMID 38076880›Full record

ArticlebioRxiv : the preprint server for biology2023

YAP localization mediates mechanical adaptation of human cancer cells during extravasation

Woong Young So, Claudia S Wong, Udochi F Azubuike, Colin D Paul, Paniz Rezvan Sangsari, Patricia B Gordon, Hyeyeon Gong, Tapan K Maity, Perry Lim, Zhilin Yang and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Woong Young SoNational Cancer Institute, National Institutes of Health (NIH), MD, USA.ORCID 0000-0002-3907-0298
Claudia S WongNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Udochi F AzubuikeNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Colin D PaulNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Paniz Rezvan SangsariNational Institute of Biomedical Imaging and Bioengineering, National Institutes of Health.
Patricia B GordonNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Hyeyeon GongNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Tapan K MaityNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Perry LimNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Zhilin YangNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Christian A HaryantoNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Eric BatchelorUniversity of Minnesota - Twin Cities, MN, USA.ORCID 0000-0003-3870-5615
Lisa M JenkinsNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
Nicole Y MorganNational Institute of Biomedical Imaging and Bioengineering, National Institutes of Health.
Kandice TannerNational Cancer Institute, National Institutes of Health (NIH), MD, USA.
National Institutes of Health · USUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biophysical profiling of primary tumors has revealed that individual tumor cells fall along a highly heterogeneous continuum of mechanical phenotypes. One idea is that a subset of tumor cells is "softer" to facilitate detachment and escape from the primary site, a step required to initiate metastasis. However, it has also been postulated that cells must be able to deform and generate sufficient force to exit into distant sites. Here, we aimed to dissect the mechanical changes that occur during extravasation and organ colonization. Using multiplexed methods of intravital microscopy and optical tweezer based active microrheology, we obtained longitudinal images and mechanical profiles of cells during organ colonization

Identifiers

PMID38076880
PMCPMC10705547
OpenAlexW4388773736

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.