Evidence map›Paper›PMID 38076834›Full record

ArticlebioRxiv : the preprint server for biology2024

Engineered

Mengdi Yang, Noah Hutchinson, Ningyuan Ye, Jianing Yin, Ming Guan, Zongqi Wang, Peiru Chen, Shaobo Yang, Justin D Crane, Ke Zhang and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Mengdi YangDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, United States.
Noah HutchinsonDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, United States.
Ningyuan YeDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, United States.
Jianing YinDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, United States.
Ming GuanDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, United States.
Zongqi WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, United States.
Peiru ChenDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, United States.
Shaobo YangDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, United States.
Justin D CraneInternal Medicine Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, MA 02139.
Ke ZhangDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, United States.
Xuesong HeDepartment of Microbiology, The Forsyth Institute, Cambridge, MA, 02142, United States.
Jiahe LiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, United States.
Northeastern University · USUniversity of Michigan · USHarvard University · USPfizer (United States) · US

Funding

Host tRNA-derived small RNAs (tsRNAs) mediate interactions between host and oral microbesR01DE030943 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Xuesong He · 2022 to 2026
$2.4M
Engineering Probiotics to Sense and Respond to the Intracellular Redox Imbalance towards Mitochondrial DysfunctionR21EB030769 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LI, JIAHE · 2021 to 2021
$611k
A New Class of Chemically Modified Small RNA Inhibitors against Fusobacterium nucleatumR03DE031329 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LI, JIAHE · 2022 to 2023
$341k
NIBIB NIH HHS R21 EB030769NIDCR NIH HHS R01 DE030943NIDCR NIH HHS R03 DE031329
6 · The paper itself

Abstract

Elevated lactate concentrations are implicated in various acute and chronic diseases such as sepsis and mitochondrial dysfunction, respectively. Conversely, ineffective lactate clearance is associated with poor clinical prognoses and high mortality in these diseases. While several groups have proposed using small molecule inhibitors and enzyme replacement to reduce circulating lactate, there are few practical and effective ways to manage this condition. Recent evidence suggests that lactate is exchanged between systemic circulation and the gut, allowing bidirectional modulation between the gut microbiota and peripheral tissues. Inspired by these findings, this work seeks to engineer spore-forming probiotic

Identifiers

PMID38076834
PMCPMC10705430
OpenAlexW4389257647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.