Evidence map›Paper›PMID 38076828›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species.

David J Gregory, Feifei Han, Peng Li, Marina Gritsenko, Jennifer Kyle, Frank E Riley, Deborah Chavez, Vania Yotova, Renata H M Sindeaux, Mohamed B F Hawash and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

David J GregoryDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-6534-7150
Feifei HanHarvard Medical School, Boston, MA, USA.ORCID 0000-0003-4373-8753
Peng LiHarvard Medical School, Boston, MA, USA.
Marina GritsenkoBiological Sciences Division, Pacific Northwest National Laboratory, Richland WA, USA.
Jennifer KyleBiological Sciences Division, Pacific Northwest National Laboratory, Richland WA, USA.
Frank E RileyDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
Deborah ChavezSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio TX, USA.
Vania YotovaCentre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
Renata H M SindeauxCentre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
Mohamed B F HawashCentre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
Fengyun XuDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA.
Li-Yuan HungDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Douglas L HaydenHarvard Medical School, Boston, MA, USA.
Ron G TompkinsHarvard Medical School, Boston, MA, USA.
Robert E LanfordSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio TX, USA.ORCID 0000-0003-4980-2920
Lester KobzikProgram in Molecular and Integrative Physiological Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Judith HellmanDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2278-6625
Jonathan M JacobsBiological Sciences Division, Pacific Northwest National Laboratory, Richland WA, USA.
Luis B BarreiroCentre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
Wenzhong XiaoHarvard Medical School, Boston, MA, USA.ORCID 0000-0003-4944-6380
H Shaw WarrenDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0005-1128-7056
Harvard University · USCentre Hospitalier Universitaire Sainte-Justine · CAPacific Northwest National Laboratory · USTexas Biomedical Research Institute · USUniversity of California, San Francisco · USMassachusetts General Hospital · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Viral Testing CoreU42OD010442 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Deepak Kaushal, Kathryn Shelton · 2012 to 2026
$35.6M
Equipment Supplement Request for a Research Resource for Ultra-sensitive High Throughput ProteomicsP41GM103493 · NIGMS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2012 to 2022
$22.6M
NIGMS NIH HHS P41 GM103493NIH HHS P51 OD011133NIH HHS U42 OD010442
6 · The paper itself

Abstract

Vertebrates differ greatly in responses to pro-inflammatory agonists such as bacterial lipopolysaccharide (LPS), complicating use of animal models to study human sepsis or inflammatory disorders. We compared transcriptomes of resting and LPS-exposed blood from six LPS-sensitive species (rabbit, pig, sheep, cow, chimpanzee, human) and four LPS-resilient species (mice, rats, baboon, rhesus), as well as plasma proteomes and lipidomes. Unexpectedly, at baseline, sensitive species already had enhanced expression of LPS-responsive genes relative to resilient species. After LPS stimulation, maximally different genes in resilient species included genes that detoxify LPS, diminish bacterial growth, discriminate sepsis from SIRS, and play roles in autophagy and apoptosis. The findings reveal the molecular landscape of species differences in inflammation, and may inform better selection of species for pre-clinical models.

Identifiers

PMID38076828
PMCPMC10705660
OpenAlexW4389163312

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.