Evidence map›Paper›PMID 38076807›Full record

ArticlebioRxiv : the preprint server for biology2024

Pain persists in mice lacking both Substance P and CGRPα signaling.

Donald Iain MacDonald, Monessha Jayabalan, Jonathan Seaman, Rakshita Balaji, Alec Nickolls, Alexander Chesler

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Donald Iain MacDonaldNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, United States.
Monessha JayabalanNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, United States.
Jonathan SeamanNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, United States.
Rakshita BalajiNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, United States.
Alec NickollsNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, United States.
Alexander CheslerNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, United States.ORCID 0000-0002-3131-0728
National Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuropeptides Substance P and CGRPα have long been thought important for pain sensation. Both peptides and their receptors are expressed at high levels in pain-responsive neurons from the periphery to the brain making them attractive therapeutic targets. However, drugs targeting these pathways individually did not relieve pain in clinical trials. Since Substance P and CGRPα are extensively co-expressed we hypothesized that their simultaneous inhibition would be required for effective analgesia. We therefore generated

Indexed as

CGRPchronic paininflammatory painneuropathic painneuropeptidesnociceptionSubstance P

Identifiers

PMID38076807
PMCPMC10705526
OpenAlexW4388757656

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.