Evidence map›Paper›PMID 38076805›Full record

ArticlebioRxiv : the preprint server for biology2023

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors.

Debanjan Bhattacharya, Riccardo Barille, Donatien Kamdem Toukam, Vaibhavkumar S Gawali, Laura Kallay, Taukir Ahmed, Hawley Brown, Sepideh Rezvanian, Aniruddha Karve, Pankaj B Desai and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 1 country.

Debanjan Bhattacharya
Riccardo Barille
Donatien Kamdem Toukam
Vaibhavkumar S Gawali
Laura Kallay
Taukir Ahmed
Hawley Brown
Sepideh Rezvanian
Aniruddha Karve
Pankaj B Desai
Mario Medvedovic
Kyle Wang
Dan Ionascu
Nusrat Harun
Chenran Wang
Andrew M Baschnagel
Joshua A Kritzer
James M Cook
Daniel A Pomeranz Krummel
Soma SenguptaORCID 0000-0003-4577-1397
University of Cincinnati Medical Center · USUniversity of Wisconsin–Milwaukee · USTufts University · USUniversity of Cincinnati · USUniversity of North Carolina at Chapel Hill · USCincinnati Children's Hospital Medical Center · USUniversity of Wisconsin–Madison · US

Funding

Diversity Supplement for Imani McDonald - Developing Autophagy-Targeting Chimeras and Optimizing Cell Penetration of Large-Molecule TherapeuticsR35GM148407 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI Joshua A Kritzer · 2023 to 2026
$2.6M
NIGMS NIH HHS R35 GM148407
6 · The paper itself

Abstract

In non-small cell lung cancer (NSCLC) treatment, targeted therapies benefit only a subset of NSCLC, while radiotherapy responses are not durable and toxicity limits therapy. We find that a GABA(A) receptor activator, AM-101, impairs viability and clonogenicity of NSCLC primary and brain metastatic cells. Employing an Highlights: Activating GABA(A) receptors intrinsic to lung primary and metastatic brain cancer cells triggers a cytotoxic response. GABA(A) receptor activation works as well as chemotherapeutic docetaxel in impairing lung cancer viability

Identifiers

PMID38076805
PMCPMC10705483
OpenAlexW4389259035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.