Evidence map›Paper›PMID 38076797›Full record

ArticlemedRxiv : the preprint server for health sciences2023

SUPRASPINAL CONTROL OF MOTONEURONS AFTER PARALYSIS ENABLED BY SPINAL CORD STIMULATION.

Josep-Maria Balaguer, Genis Prat-Ortega, Nikhil Verma, Prakarsh Yadav, Erynn Sorensen, Roberto de Freitas, Scott Ensel, Luigi Borda, Serena Donadio, Lucy Liang and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 3 countries.

Josep-Maria BalaguerRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0002-7792-6376
Genis Prat-OrtegaRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0002-3401-3569
Nikhil VermaDept. of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, US.
Prakarsh YadavDept. of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, US.ORCID 0000-0002-1170-6290
Erynn SorensenRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0003-0988-4132
Roberto de FreitasRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.
Scott EnselRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0003-0264-3686
Luigi BordaDept. of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, US.
Serena DonadioRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0002-2425-6145
Lucy LiangRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.ORCID 0009-0003-5462-832X
Jonathan HoRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.
Arianna DamianiRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.ORCID 0009-0002-8521-865X
Erinn GrigsbyRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0002-8378-6488
Daryl P FieldsRehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0002-4594-2996
Jorge A Gonzalez-MartinezDept. of Neurological Surgery, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0002-9936-7034
Peter C GersztenDept. of Neurological Surgery, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0002-1483-6090
Lee E FisherDept. of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, US.
Douglas J WeberDept. of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, US.ORCID 0000-0002-9782-3497
Elvira PirondiniDept. of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0002-8078-3951
Marco CapogrossoDept. of Neurological Surgery, University of Pittsburgh, Pittsburgh, US.ORCID 0000-0002-0975-316X
University of Pittsburgh · USCarnegie Mellon University · USNeuroscience Institute · IT

Funding

Spinal Cord Stimulation to Improve Motor Function in People with Post-Stroke HemiplegiaUG3NS123135 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAPOGROSSO, MARCO, WEBER, DOUGLAS J · 2022 to 2024
$4.7M
NINDS NIH HHS UG3 NS123135
6 · The paper itself

Abstract

Spinal cord stimulation (SCS) restores motor control after spinal cord injury (SCI) and stroke. This evidence led to the hypothesis that SCS facilitates residual supraspinal inputs to spinal motoneurons. Instead, here we show that SCS does not facilitate residual supraspinal inputs but directly triggers motoneurons action potentials. However, supraspinal inputs can shape SCS-mediated activity, mimicking volitional control of motoneuron firing. Specifically, by combining simulations, intraspinal electrophysiology in monkeys and single motor unit recordings in humans with motor paralysis, we found that residual supraspinal inputs transform subthreshold SCS-induced excitatory postsynaptic potentials into suprathreshold events. We then demonstrated that only a restricted set of stimulation parameters enables volitional control of motoneuron firing and that lesion severity further restricts the set of effective parameters. Our results explain the facilitation of voluntary motor control during SCS while predicting the limitations of this neurotechnology in cases of severe loss of supraspinal axons.

Identifiers

PMID38076797
PMCPMC10705627
OpenAlexW4389273709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.