Evidence map›Paper›PMID 38076729›Full record

ArticleInternational journal of nanomedicine2023

Hollow Mesoporous Molybdenum Single-Atom Nanozyme-Based Reactor for Enhanced Cascade Catalytic Antibacterial Therapy.

Zhijun Zhang, Tiehong Yang, Jingwei Wang, Zhe Yu, Youbei Qiao, Chaoli Wang, Zhenggang Yue, Hong Wu

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhijun ZhangSchool of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, People's Republic of China.ORCID 0009-0002-8053-4012
Tiehong YangDepartment of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an, People's Republic of China.
Jingwei WangDepartment of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an, People's Republic of China.
Zhe YuDepartment of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an, People's Republic of China.
Youbei QiaoDepartment of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an, People's Republic of China.ORCID 0000-0002-7034-4373
Chaoli WangDepartment of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an, People's Republic of China.
Zhenggang YueSchool of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, People's Republic of China.
Hong WuDepartment of Medicine Chemistry and Pharmaceutical Analysis, School of Pharmacy, Air Force Medical University, Xi'an, People's Republic of China.ORCID 0000-0002-4939-5264

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The remarkable peroxidase-like activity of single-atom nanozymes (SAzymes) allows them to catalyze the conversion of H Methods: We developed a hollow mesoporous molybdenum single-atom nanozyme (HMMo-SAzyme) using a controlled chemical etching approach and pyrolysis strategy. The HMMo-SAzyme not only exhibited excellent catalytic activity but also served as an effective nanocarrier. By loading glucose oxidase (GOx) with HMMo-SAzyme and encapsulating it with hyaluronic acid (HA), a nanoreactor (HMMo/GOx@HA) was constructed as glucose-triggered cascade catalyst for combating bacterial infection in vivo. Results: Hyaluronidase (HAase) at the site of infection degraded HA, allowing GOx to convert glucose into gluconic acid and H Conclusion: This study represents a significant advancement in developing a cascade catalytic system with high efficiency based on hollow mesoporous SAzyme, promising the advancement of biological applications of SAzyme.

Indexed as

Hydrogen PeroxideMolybdenumAnti-Bacterial AgentsCatalysisGlucoseGlucose OxidaseHyaluronic AcidAnti-Bacterial AgentsGlucoseGlucose OxidaseHyaluronic AcidHydrogen PeroxideMolybdenumbacterial infectionglucose oxidasenanocarriernanozymereactive oxygen species

Identifiers

PMID38076729
PMCPMC10710243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.