Evidence map›Paper›PMID 38076529›Full record

ArticleCrystal growth & design2023

New Solid Forms of Griseofulvin: A Solvate and a Relict Polymorph Related to Reported Solvates.

Mariana O Diniz, Enrico Spoletti, Peuli Ghosh, Matteo Lusi, Michael Svärd, Åke Rasmuson, Sarah P Hudson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Crystal growth & design, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariana O DinizSSPC, the Science Foundation Ireland Research Centre for Pharmaceuticals, University of Limerick, Limerick V94 T9PX, Ireland.
Enrico SpolettiDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Peuli GhoshSSPC, the Science Foundation Ireland Research Centre for Pharmaceuticals, University of Limerick, Limerick V94 T9PX, Ireland.
Matteo LusiDepartment of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Michael SvärdDepartment of Chemical Engineering, KTH Royal Institute of Technology, Stockholm SE-100 44, Sweden.ORCID https://orcid.org/0000-0002-6647-3308
Åke RasmusonSSPC, the Science Foundation Ireland Research Centre for Pharmaceuticals, University of Limerick, Limerick V94 T9PX, Ireland.
Sarah P HudsonSSPC, the Science Foundation Ireland Research Centre for Pharmaceuticals, University of Limerick, Limerick V94 T9PX, Ireland.ORCID https://orcid.org/0000-0002-6718-2190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work presents two new solid forms, a polymorph and a solvate, of the antifungal active pharmaceutical ingredient griseofulvin (GSF). The novel forms were characterized by powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis, and their crystal structures were determined by single-crystal X-ray diffraction. The new polymorphic form (GSF Form VI) was obtained upon drying at room temperature the GSF-acetonitrile solvate. GSF Form VI is a relict structure related to reported solvates of GSF. Thermal stability studies show that Form VI is metastable and monotropically related to the stable GSF Form I. The new GSF-

Identifiers

PMID38076529
PMCPMC10704485

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.