Evidence map›Paper›PMID 38076520›Full record

ArticleArXiv2023

Mediation Analysis using Semi-parametric Shape-Restricted Regression with Applications.

Qing Yin, Jong-Hyeon Jeong, Xu Qin, Shyamal D Peddada, Jennifer J Adibi

Open access · greenAbstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qing YinDepartment of Biostatistics, University of Pittsburgh.
Jong-Hyeon JeongDepartment of Biostatistics, University of Pittsburgh.
Xu QinDepartment of Health and Human Development, University of Pittsburgh.
Shyamal D PeddadaBiostatistics and Bioinformatics Branch, NICHD.
Jennifer J AdibiDepartment of Epidemiology, University of Pittsburgh.
University of Pittsburgh · US

Funding

Placental origins of phthalate-induced changes in fetal reproductive developmentR01ES029336 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ADIBI, JENNIFER JOAN · 2018 to 2023
$3.5M
NIEHS NIH HHS R01 ES029336
6 · The paper itself

Abstract

Often linear regression is used to perform mediation analysis. However, in many instances, the underlying relationships may not be linear, as in the case of placentalfetal hormones and fetal development. Although, the exact functional form of the relationship may be unknown, one may hypothesize the general shape of the relationship. For these reasons, we develop a novel shape-restricted inference-based methodology for conducting mediation analysis. This work is motivated by an application in fetal endocrinology where researchers are interested in understanding the effects of pesticide application on birth weight, with human chorionic gonadotropin (hCG) as the mediator. We assume a practically plausible set of nonlinear effects of

Indexed as

Birth-weightConstrained inferenceHuman chorionic gonadotropin (hCG)Mediation analysisPesticides exposurePlacental-fetal hormonesRegression splineShape-restricted inference

Identifiers

PMID38076520
PMCPMC10705571
OpenAlexW4387687975

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.