Evidence map›Paper›PMID 38076511›Full record

ArticleArXiv2023

Compact Electrochromic Optical Recording of Bioelectric Potentials.

Kenneth Nakasone, Chris Zavik, Erica Liu, Burhan Ahmed, Dana Griffith, Lothar Maisenbacher, Ashwin Singh, Yuecheng Zhou, Bianxiao Cui, Holger Müller

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kenneth NakasoneDepartment of Physics, 366 Physics South, University of California, Berkeley, CA 94720.
Chris ZavikDepartment of Physics, 366 Physics South, University of California, Berkeley, CA 94720.
Erica LiuDepartment of Chemistry, 290 Jane Stanford Way, Stanford University, Stanford, CA 94305.
Burhan AhmedDepartment of Physics, 366 Physics South, University of California, Berkeley, CA 94720.
Dana GriffithDepartment of Physics, 366 Physics South, University of California, Berkeley, CA 94720.
Lothar MaisenbacherDepartment of Physics, 366 Physics South, University of California, Berkeley, CA 94720.
Ashwin SinghDepartment of Physics, 366 Physics South, University of California, Berkeley, CA 94720.
Yuecheng ZhouDepartment of Chemistry, 290 Jane Stanford Way, Stanford University, Stanford, CA 94305.
Bianxiao CuiDepartment of Chemistry, 290 Jane Stanford Way, Stanford University, Stanford, CA 94305.
Holger MüllerDepartment of Physics, 366 Physics South, University of California, Berkeley, CA 94720.

Funding

Label-free Optical Recording of Neuroelectric ActivitiesR01NS121934 · NINDS · STANFORD UNIVERSITY · PI CUI, BIANXIAO, MUELLER, HOLGER · 2021 to 2025
$2.2M
NINDS NIH HHS R01 NS121934
6 · The paper itself

Abstract

Electrochromic optical recording (ECORE) is a label-free method that utilizes electrochromism to optically detect electrical signals in biological cells with a high signal-to-noise ratio and is suitable for long-term recording. However, ECORE usually requires a large and intricate optical setup, making it relatively difficult to transport and to study specimens on a large scale. Here, we present a Compact ECORE (CECORE) apparatus that drastically reduces the spatial footprint and complexity of the ECORE setup whilst maintaining high sensitivity. An autobalancing differential photodetector automates common-mode noise rejection, removing the need for manually adjustable optics, and a compact laser module conserves space compared to a typical laser mount. The result is a simple, easy-to-use, and relatively low cost system that achieves a sensitivity of 16.7 μV (within a factor of 5 of the shot noise limit), and reliably detects action potentials from Human-induced pluripotent stem cell (HiPSC) derived cardiomyocytes. This setup can be further improved to within 1.5 dB of the shot noise limit by filtering out power-line interference.

Identifiers

PMID38076511
PMCPMC10705589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.