Evidence map›Paper›PMID 38076209›Full record

ArticleFrontiers in molecular neuroscience2023

Activation of the spinal and brainstem locomotor networks during free treadmill stepping in rats lacking dopamine transporter.

Aleksandr Veshchitskii, Polina Shkorbatova, Aleksandr Mikhalkin, Zoja Fesenko, Evgeniya V Efimova, Raul R Gainetdinov, Natalia Merkulyeva

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In one paragraph

Article in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aleksandr VeshchitskiiNeuromorphology Laboratory, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Polina ShkorbatovaNeuromorphology Laboratory, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Aleksandr MikhalkinNeuromorphology Laboratory, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.
Zoja FesenkoInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.
Evgeniya V EfimovaInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.
Raul R GainetdinovInstitute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.
Natalia MerkulyevaNeuromorphology Laboratory, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine is extremely important for the multiple functions of the brain and spinal cord including locomotor behavior. Extracellular dopamine levels are controlled by the membrane dopamine transporter (DAT), and animals lacking DAT (DAT-KO) are characterized by hyperdopaminergia and several alterations of locomotion including hyperactivity. Neuronal mechanisms of such altered locomotor behavior are still not fully understood. We believe that in hyperdopaminergic animals both the spinal and brain neuronal networks involved in locomotion are modified. Using the

Indexed as

c-fosdopamine transportermesencephalic locomotor areaspinal cordtreadmill locomotionventrolateral periaqueductal gray

Identifiers

PMID38076209
PMCPMC10702542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.