ReviewFrontiers in cardiovascular medicine2023
Lower limb arterial calcification and its clinical relevance with peripheral arterial disease.
Review in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Long-term outcomes of the "pave-and-crack" technique for severely calcified femoropopliteal chronic total occlusions.CVIR endovascular · 2026Article
- Five-Year Outcomes of Endovascular Aortoiliac Reconstruction in Complex Lesions: A Retrospective Single-Center Study.Journal of clinical medicine · 2026Article
- Association Between DOAC Exposure and Lower-Extremity Arterial Calcification: A Propensity-Matched Exploratory CT Study.Journal of clinical medicine · 2026Article
- Development of risk prediction model for major amputation in patients with diabetic foot.BMC endocrine disorders · 2026Article
- Predicting Antegrade Success in Femoropopliteal Occlusions Using Radiological and Clinical Machine Learning Models.Cardiovascular and interventional radiology · 2026Article
- Peripheral Vascular Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Noncontrast magnetic resonance angiography outperforms digital subtraction angiography in detecting hibernating below-the-knee arteries and downgrades Transatlantic Inter-Society Consensus and Global Limb Anatomic Staging System scores in chronic limb-threatening ischemia patients.Journal of vascular surgery · 2026Observational
- Histological concordance of medial arterial calcification between tibial and peroneal arteries in advanced peripheral arterial disease.JVS-vascular science · 2026Article
- Endovascular management of superficial femoral artery chronic total occlusions: Influence of lesion complexity and popliteal access on the efficacy of rotational atherectomy plus drug-coated balloon versus drug-coated balloon alone.Journal of clinical imaging science · 2026Article
- Atherosclerosis features in rheumatic diseases - focus on peripheral artery disease.Frontiers in immunology · 2026Review
- Clinical Characteristics and Angioplasty Outcomes in Lower Extremity Artery Disease Patients with Normal Ankle-Brachial Index: A Clinical Conundrum.Acta Cardiologica Sinica · 2025Article
- Pain Relief During Recanalization of Chronic Femoropopliteal Artery Occlusions With Use of a Crossing Catheter.JACC. Case reports · 2025Article
- Galectin-3 Reflects Systemic Atherosclerosis in Patients with Coronary Artery Disease.Medicina (Kaunas, Lithuania) · 2025Observational
- Iliac Calcium Score thresholds predict cardiovascular and limb-related outcomes in TASC D aortoiliac disease.Frontiers in medicine · 2025Article
- Comparison of Duplex Ultrasound and Digital Subtraction Angiography for Assessing Tibial Vessel Disease.Cureus · 2024Article
- Kissing intravascular lithotripsy in iliac in-stent restenosis related to underexpanded stents.Journal of vascular surgery cases and innovative techniques · 2024Article
- Safety and Feasibility of the BYCROSSJournal of clinical medicine · 2024Article
- Screening for Subclinical Atherosclerosis and the Prediction of Cardiovascular Events in People with Type 1 Diabetes.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lower limb arterial calcification (LLAC) is associated with an increased risk of mortality and it predicts poor outcomes after endovascular interventions in patients with peripheral artery disease (PAD). Detailed histological analysis of human lower artery specimens pinpointed the presence of LLAC in two distinct layers: the intima and the media. Intimal calcification has been assumed to be an atherosclerotic pathology and it is associated with smoking and obesity. It becomes instrumental in lumen stenosis, thereby playing a crucial role in disease progression. On the contrary, medial calcification is a separate process, systematically regulated and linked with age advancement, diabetes, and chronic kidney disease. It prominently interacts with vasodilation and arterial stiffness. Given that both types of calcifications frequently co-exist in PAD patients, it is vital to understand their respective mechanisms within the context of PAD. Calcification can be easily identifiable entity on imaging scans. Considering the highly improved abilities of novel imaging technologies in differentiating intimal and medial calcification within the lower limb arteries, this review aimed to describe the distinct histological and imaging features of the two types of LLAC. Additionally, it aims to provide in-depth insight into the risk factors, the effects on hemodynamics, and the clinical implications of LLAC, either occurring in the intimal or medial layers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.