ArticleFrontiers in cardiovascular medicine2023
Impact of loop diuretic dosage in a population of patients with acute heart failure: a retrospective analysis.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Comparative analysis of the addition of empagliflozin versus doubling the furosemide dose in decompensated heart failure.Cardiovascular drugs and therapy · 2025Trial
- Diuretic dosing and outcomes with torsemide and furosemide following hospitalization for heart failure: The TRANSFORM-HF trial.European journal of heart failure · 2025Trial
- Diuretic Intensity Score and Mortality in Hospitalized Heart Failure Patients: A Multicenter Propensity-Matched Analysis.Clinical cardiology · 2026Article
- Portal Vein Pulsatility: A Valuable Approach for Monitoring Venous Congestion and Prognostic Evaluation in Acute Decompensated Heart Failure.Diagnostics (Basel, Switzerland) · 2024Article
- Evaluation and Management of Hyponatremia in Heart Failure.Current heart failure reports · 2024Review
- Preliminary Report of Intravenous Tolvaptan Sodium Phosphate (SamtasJournal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Loop diuretics are essential for managing congestion in acute heart failure (AHF) patients, but concerns exist about their dosing and administration. This study aims to explore the relationship between aggressive diuretic treatment and clinical outcomes in AHF patients. Methods: We randomly selected 370 AHF patients from admissions at Maastricht University Medical Center between January 2011 and March 2017. Patients were divided into four quartiles based on diuretic doses administrated during index hospitalization. The primary endpoint was a composite of cardiovascular (CV) rehospitalization or death at 1 year. Results: 42.4% of patients experimented the primary outcome The composite endpoint rates were 35.4%, 41.6%, 38.5%, and 54.9%, respectively, from lowest to highest dose quartiles ( Conclusions: High loop diuretic doses are associated with poor outcomes in AHF patients, reflecting disease severity rather than harm from aggressive diuretic use. Furthermore, high diuretic doses do not seem to negatively affect kidney function.
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Registered trials
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