ArticleFrontiers in cardiovascular medicine2023
Global burden, trends, and inequalities of ischemic heart disease among young adults from 1990 to 2019: a population-based study.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Risk prediction models for depression in patients with coronary heart disease: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
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- WTAP Histone Lactylation Drives the YTHDF1/ALOX15 Axis to Regulate Ferroptosis in Myocardial Ischemia-Reperfusion Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Diagnostic, Prognostic and Therapeutic Utility of MicroRNA-21 in Ischemic Heart Disease.International journal of molecular sciences · 2026Review
- Global burden of ischemic heart disease attributable to dietary risks in young adults, 1990-2021: trends and future projections.Frontiers in public health · 2026Article
- Trends and projections of IHD burden attributable to dietary high sodium and kidney dysfunction in G20 countries, 1990-2050.PloS one · 2026Article
- Trials evaluating nicorandil renoprotection against contrast-induced nephropathy after coronary angiography or percutaneous coronary intervention: a systematic review and meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Review
- Ischemic heart disease mortality due to fine particulate matter in Seoul between 2016 and 2020.BMC public health · 2025Article
- DMSO-free cryopreservation of hiPSC-derived cardiomyocytes: low temperature characterization and protocol development.Stem cell research & therapy · 2025Article
- From Rehab to Routine: Ensuring Lasting Lifestyle Changes After Cardiac Rehabilitation - First Experiences from the "Love Your Heart" Program.Acta medica academica · 2025Article
- A global analysis of the burden of ischemic heart disease attributable to diet low in ω-3 fatty acids between 1990 and 2021.BMC cardiovascular disorders · 2025Article
- Small extracellular vesicles enhance the survival of Sca-1+ cardiac stem cells against ROS-induced ischemic-reoxygenation injury in vitro.Biological research · 2025Article
- Global trends in the burden of ischemic heart disease based on the global burden of disease study 2021: the role of metabolic risk factors.BMC public health · 2025Article
- Global Burden of Early-Onset Ischemic Heart Disease, 1990 to 2019.JACC. Advances · 2025Article
- An analysis of the burden of migraine and tension-type headache across the global, China, the United States, India and Japan.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Global, regional, and national burdens of ischemic heart disease in the older adults aged 60-89 years: a systematic analysis for the Global Burden of Disease Study 2019.Frontiers in cardiovascular medicine · 2025Article
- Exploring challenges to medication adherence aacmong young and middle-aged adults with coronary heart disease in China: a qualitative study.Frontiers in cardiovascular medicine · 2025Article
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- Distinct methylome profile of cfDNA in AMI patients reveals significant alteration in cAMP signaling pathway genes regulating cardiac muscle contraction.Clinical epigenetics · 2024Article
- Capillary Blood Docosahexaenoic Acid Levels Predict Electrocardiographic Markers in a Sample Population of Premenopausal Women.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ischemic heart disease (IHD) is a major global health concern, and its burden among young adults aged 25-49 years remains underexplored. This study aims to provide a comprehensive assessment of the global burden and trends of IHD over the past 30 years (1990-2019) among this age group, as well as to analyze the health inequalities related to socioeconomic development. Methods: Data from Global Burden of Disease Study 2019 (GBD 2019) were utilized to analyze the prevalence, mortality, and disability-adjusted life years (DALYs) rate of IHD among young adults globally. Joinpoint regression analysis was applied to examine the trends over the study period. Health inequality analysis was performed to investigate the disparities in IHD burden related to the Socio-Demographic Index (SDI) of countries. Results: According to GBD 2019 data, in 2019, the global numbers of young adults with IHD cases, deaths, and DALYs were 18,050,671 (95% UI, 15,551,940-21,254,746), 597,137 (548,250-647,778), and 28,692,968 (26,397,448-31,178,464), respectively, accounting for 9.15%, 6.53%, and 15.7% of the total global cases. Over the past 30 years, the mortality [AAPC = -0.4%, 95% CI (-0.7% to -0.1%)] and DALYs rate [AAPC = -0.3%, 95% CI (-0.6% to -0.1%)] of IHD among young adults decreased, while the prevalence rate [AAPC = 0.4%, 95% CI (0.4%-0.4%)] and YLDs rate [AAPC = 0.4%, 95% CI (0.3%-0.4%)] increased. Furthermore, countries with lower levels of socio-demographic index (SDI) disproportionately bore a higher burden of IHD among young adults. The inequality slope index for young adult IHD shifted from -56.6 [95% CI (-480.4-370.2)] in 1990 to -583.0 [95% CI (-996.8 to -169.2)] in 2019, and the concentration index moved from -8.2 [95% CI (-8.5 to -7.9)] in 1990 to -13.2 [95% CI (-13.9 to -12.4)] in 2019. Conclusions: While the mortality and DALYs rate of IHD among global young adults have decreased over the past 30 years, the degree of inequality related to SDI among countries has continued to increase. Decision-makers in various countries should allocate resources wisely and implement effective strategies to improve the burden of young adults IHD globally and address the health inequalities associated with it.
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