Evidence map›Paper›PMID 38075938›Full record

ArticleJournal of bone oncology2023

Evaluation of pain related behaviors and disease related outcomes in an immunocompetent mouse model of prostate cancer induced bone pain.

Juan Miguel Jimenez-Andrade, Martha B Ramírez-Rosas, Sun Hee Park, Renee Parker, Matthew R Eber, Rebecca Cain, Mary Newland, Fang-Chi Hsu, Carol A Kittel, Thomas J Martin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Between Prometheus and Thanatos: Reflections on Intracardiac Injection Models for Metastasis in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Juan Miguel Jimenez-AndradeUniversidad Autónoma de Tamaulipas, Campus Reynosa Aztlán, Reynosa, Tamaulipas, 88700 Mexico.
Martha B Ramírez-RosasUniversidad Autónoma de Tamaulipas, Campus Reynosa Aztlán, Reynosa, Tamaulipas, 88700 Mexico.
Sun Hee ParkDepartment of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Renee ParkerDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Matthew R EberDepartment of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Rebecca CainDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Mary NewlandDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Fang-Chi HsuDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Carol A KittelDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Thomas J MartinDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Enriqueta Muñoz-IslasUniversidad Autónoma de Tamaulipas, Campus Reynosa Aztlán, Reynosa, Tamaulipas, 88700 Mexico.
Yusuke ShiozawaDepartment of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Christopher M PetersDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Wake Forest University · USAutonomous University of Tamaulipas · MX

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
The contributions of sensory nerves to bone metastasis and associated bone painR01CA238888 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SHIOZAWA, YUSUKE · 2020 to 2024
$1.8M
Dissecting Neural Circuits Involved in Musculoskeletal PainR21AR078366 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PETERS, CHRISTOPHER MICHAEL · 2021 to 2022
$367k
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA238888NIAMS NIH HHS R21 AR078366
6 · The paper itself

Abstract

Cancer-induced bone pain (CIBP) is the most common and devastating symptom of bone metastatic cancer that substantially disrupts patients' quality of life. Currently, there are few effective analgesic treatments for CIBP other than opioids which come with severe side effects. In order to better understand the factors and mechanisms responsible for CIBP it is essential to have clinically relevant animal models that mirror pain-related symptoms and disease progression observed in patients with bone metastatic cancer. In the current study, we characterize a syngeneic mouse model of prostate cancer induced bone pain. We transfected a prostate cancer cell line (RM1) with green fluorescent protein (GFP) and luciferase reporters in order to visualize tumor growth longitudinally

Indexed as

Bone metastasisMalignant bone painNociceptorOncology

Identifiers

PMID38075938
PMCPMC10701434
OpenAlexW4388107700

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.