Evidence map›Paper›PMID 38075741›Full record

ArticleACS omega2023

Manipulating Diastereomeric Bicyclononynes to Sensitively Determine Enzyme Activity and Facilitate Macromolecule Conjugations.

Chien-Hui Huang, Sin-Yu Hou, Scott Severance, Chi-Ching Hwang, Bo-Kai Fang, Ming-Mao Gong, Siao-Lei Yu, Yung-Chieh Weng, Li-Fang Wang, Chia-Yen Dai and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chien-Hui HuangDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Sin-Yu HouDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Scott SeveranceDepartment of Molecular and Cellular Sciences, Liberty University College of Osteopathic Medicine, Lynchburg, Virginia 24515, United States.
Chi-Ching HwangDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Bo-Kai FangDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Ming-Mao GongDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Siao-Lei YuDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yung-Chieh WengDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Li-Fang WangDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chia-Yen DaiDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Su-Hung WangDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chi Mei Hospital, Tainan 72263, Taiwan.
Hsing-Tao KuoDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chi Mei Hospital, Tainan 72263, Taiwan.
Jeh-Jeng WangDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID https://orcid.org/0000-0002-3148-1885
Tzu-Pin WangDepartment of Medicinal and Applied Chemistry, Department of Biochemistry, School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID https://orcid.org/0000-0003-3668-7329

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bicyclo[6.1.0]nonyne (BCN) is one of the most commonly used cycloalkynes in strain-promoted azide-alkyne cycloaddition (SPAAC). The synthesis of BCN produces two diastereomers,

Identifiers

PMID38075741
PMCPMC10702302

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.