Evidence map›Paper›PMID 38075699›Full record

ArticleFrontiers in genetics2023

Case report: Neonatal-onset inflammatory bowel disease due to novel compound heterozygous mutations in

Andrea Finocchi, Lucia Pacillo, Maria Chiriaco, Gigliola Di Matteo, Paola Francalanci, Giulia Angelino, Tamara Caldaro, Beatrice Rivalta, Maurice O'Mara, Suisheng Zhang and 5 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. De novo DUOX2 expression in neutrophil subsets shapes the pathogenesis of intestinal disease.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Andrea FinocchiResearch Unit of Primary Immunodeficiencies, Unit of Clinical Immunology and Vaccinology, IRCCS Bambino Gesù Children Hospital, Rome, Italy.
Lucia PacilloResearch Unit of Primary Immunodeficiencies, Unit of Clinical Immunology and Vaccinology, IRCCS Bambino Gesù Children Hospital, Rome, Italy.
Maria ChiriacoResearch Unit of Primary Immunodeficiencies, Unit of Clinical Immunology and Vaccinology, IRCCS Bambino Gesù Children Hospital, Rome, Italy.
Gigliola Di MatteoResearch Unit of Primary Immunodeficiencies, Unit of Clinical Immunology and Vaccinology, IRCCS Bambino Gesù Children Hospital, Rome, Italy.
Paola FrancalanciIRCCS Bambino Gesù Children's Hospital, Unit of Pathology, Rome, Italy.
Giulia AngelinoIRCCS Bambino Gesù Children's Hospital, Digestive Endoscopy and Surgery Unit, Rome, Italy.
Tamara CaldaroIRCCS Bambino Gesù Children's Hospital, Digestive Endoscopy and Surgery Unit, Rome, Italy.
Beatrice RivaltaResearch Unit of Primary Immunodeficiencies, Unit of Clinical Immunology and Vaccinology, IRCCS Bambino Gesù Children Hospital, Rome, Italy.
Maurice O'MaraSchool of Medicine, Conway Institute, University College Dublin, Dublin, Ireland.
Suisheng ZhangSchool of Medicine, Conway Institute, University College Dublin, Dublin, Ireland.
Francesca Romana LepriLaboratory of Medical Genetics, IRCCS Bambino Gesù Children's Hospital, Translational Cytogenomics Research Unit, Rome, Italy.
Antonio NovelliLaboratory of Medical Genetics, IRCCS Bambino Gesù Children's Hospital, Translational Cytogenomics Research Unit, Rome, Italy.
Paola De AngelisIRCCS Bambino Gesù Children's Hospital, Digestive Endoscopy and Surgery Unit, Rome, Italy.
Ulla G KnausSchool of Medicine, Conway Institute, University College Dublin, Dublin, Ireland.
Francesca ReaIRCCS Bambino Gesù Children's Hospital, Digestive Endoscopy and Surgery Unit, Rome, Italy.
Bambino Gesù Children's Hospital · ITUniversity College Dublin · IEUniversity of Rome Tor Vergata · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Very Early Onset Inflammatory Bowel Disease (VEO-IBD) is potentially associated with genetic disorders of the intestinal epithelial barrier or inborn errors of immunity (IEI). Dual oxidase 2 (DUOX2), an H

Indexed as

DUOX2inflammatory bowel diseaseNADPH oxidaseneonatal-IBDVEO-IBD

Identifiers

PMID38075699
PMCPMC10701422
OpenAlexW4388944890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.