Evidence map›Paper›PMID 38075656›Full record

ArticleChemical science2023

Chemoselective bond activation by unidirectional and asynchronous PCET using ketone photoredox catalysts.

Rui Sun, Serge Ruccolo, Daniel L Nascimento, Yangzhong Qin, Nathaniel Hibbert, Daniel G Nocera

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rui SunDepartment of Chemistry and Chemical Biology, Harvard University 12 Oxford Street Cambridge MA 02138 USA dnocera@fas.harvard.edu.ORCID https://orcid.org/0000-0002-3894-8425
Serge RuccoloDepartment of Chemistry and Chemical Biology, Harvard University 12 Oxford Street Cambridge MA 02138 USA dnocera@fas.harvard.edu.ORCID https://orcid.org/0000-0002-4297-2751
Daniel L NascimentoDepartment of Chemistry and Chemical Biology, Harvard University 12 Oxford Street Cambridge MA 02138 USA dnocera@fas.harvard.edu.ORCID https://orcid.org/0000-0002-9363-2175
Yangzhong QinDepartment of Chemistry and Chemical Biology, Harvard University 12 Oxford Street Cambridge MA 02138 USA dnocera@fas.harvard.edu.
Nathaniel HibbertDepartment of Chemistry and Chemical Biology, Harvard University 12 Oxford Street Cambridge MA 02138 USA dnocera@fas.harvard.edu.
Daniel G NoceraDepartment of Chemistry and Chemical Biology, Harvard University 12 Oxford Street Cambridge MA 02138 USA dnocera@fas.harvard.edu.ORCID https://orcid.org/0000-0001-5055-320X
Harvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The triplet excited states of ketones are found to effect selective H-atom abstraction from strong amide N-H bonds in the presence of weaker C-H bonds through a proton-coupled electron transfer (PCET) pathway. This chemoselectivity, which results from differences in ionization energies (IEs) between functional groups rather than bond dissociation energies (BDEs) arises from the asynchronicity between electron and proton transfer in the PCET process. We show how this strategy may be leveraged to achieve the intramolecular anti-Markovnikov hydroamidation of alkenes to form lactams using camphorquinone as an inexpensive and sustainable photocatalyst.

Identifiers

PMID38075656
PMCPMC10699566
OpenAlexW4388240179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.