ArticleEFSA journal. European Food Safety Authority2023
Scientific opinion on the tolerable upper intake level for manganese.
Article in EFSA journal. European Food Safety Authority, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Manganese-derived biomaterials for tumor diagnosis and therapy.Journal of nanobiotechnology · 2024Pooled it
- Safety of frozen paste from blanched, whole migratory locust (EFSA journal. European Food Safety Authority · 2026Article
- Study on Natural Background Levels of Iron and Manganese in Groundwater of Yinchuan Plain.Water environment research : a research publication of the Water Environment Federation · 2026Article
- Persistent effects of pre-differentiation manganese exposure on adipogenesis and metabolic function in differentiated 3T3-L1 adipocyte cells.Journal of hazardous materials advances · 2026Article
- Censored-Data-Aware Screening of Hazardous Metal(loid)s in Wild Mushrooms from Urban and Peri-Urban Green Spaces: Multielement Fingerprints and Adult Exposure Assessment.Journal of xenobiotics · 2026Article
- Developmental manganese exposure, but not concurrent lead, alters social processing selectively in male mice.iScience · 2026Article
- A manganese-luteolin co-loaded antioxidant hydrogel for synergistic alleviation of oxidative stress and immunomodulation in intervertebral disc degeneration.Materials today. Bio · 2026Article
- Health risk assessment and ionomic profiling under cadmium, lead, zinc, and manganese stress in Amaranthus cruentus.BMC plant biology · 2026Article
- ICP-MS determination of trace metals in commercial cornflakes from the UAE market.Scientific reports · 2026Article
- Metal Content inFoods (Basel, Switzerland) · 2026Article
- Essential Trace Elements in Edible Plants: Balancing Nutritional Benefits and Potential Health Risks.Journal of agricultural and food chemistry · 2026Article
- Dietary Exposure and Health Risk Assessment of Selected Toxic and Essential Metals in Various Flavored Dairy Products.Biological trace element research · 2026Article
- Evaluation of the Elemental Composition of Dietary Supplements Containing Iron Available on the Polish Market Using ICP-OES, FAAS and CVAAS Techniques.Molecules (Basel, Switzerland) · 2025Article
- Chicken Liver from Broilers Fed Wheat Germ Expeller: A Source of Minerals and Energy in the Human Diet.Foods (Basel, Switzerland) · 2025Article
- The Role of Antioxidant Minerals in the Pathophysiology and Treatment of Endometriosis-Systematic Review.Antioxidants (Basel, Switzerland) · 2025Review
- Effects of Mn Deficiency on Hepatic Oxidative Stress, Lipid Metabolism, Inflammatory Response, and Transcriptomic Profile in Mice.Nutrients · 2025Article
- Manganese Neurotoxicity and Familial Disorders of Manganese Transport.Annals of the Child Neurology Society · 2025Review
- Manganese exposure assessment in formula-fed infants in Israel.Israel journal of health policy research · 2025Article
- Article
- Exposure to Cadmium and Other Trace Elements Among Individuals with Mild Cognitive Impairment.Toxics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following a request from the European Commission (EC), the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the tolerable upper intake level (UL) for manganese. Systematic reviews of the literature of human and animal data were conducted to assess evidence regarding excess manganese intake (including authorised manganese salts) and the priority adverse health effect, i.e. manganese-induced neurotoxicity. Available human and animal studies support neurotoxicity as a critical effect, however, data are not sufficient and suitable to characterise a dose-response relationship and identify a reference point for manganese-induced neurotoxicity. In the absence of adequate data to establish an UL, estimated background dietary intakes (i.e. manganese intakes from natural dietary sources only) observed among high consumers (95th percentile) were used to provide an indication of the highest level of intake where there is reasonable confidence on the absence of adverse effects. A safe level of intake of 8 mg/day was established for adults ≥ 18 years (including pregnant and lactating women) and ranged between 2 and 7 mg/day for other population groups. The application of the safe level of intake is more limited than an UL because the intake level at which the risk of adverse effects starts to increase is not defined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.