Evidence map›Paper›PMID 38075561›Full record

ArticleJournal of the Endocrine Society2023

The Association of Prenatal Vitamin D Status With Pregnancy and Neonatal Outcomes.

Di Mao, Lai-Yuk Yuen, Chung-Shun Ho, Chi-Chiu Wang, Claudia Ha-Ting Tam, Michael Ho-Ming Chan, William L Lowe, Ronald Ching-Wan Ma, Wing-Hung Tam

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Di MaoDepartment of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-0215-5941
Lai-Yuk YuenDepartment of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0003-2249-1077
Chung-Shun HoDepartment of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chi-Chiu WangDepartment of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-3928-7278
Claudia Ha-Ting TamDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Michael Ho-Ming ChanDepartment of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
William L LoweDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Ronald Ching-Wan MaLi Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-1227-803X
Wing-Hung TamDepartment of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0003-1189-740X
Chinese University of Hong Kong · HKNorthwestern University · US

Funding

Hyperglycemia and Adverse Pregnancy Outcome (HAPO)R01HD034243 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI METZGER, BOYD E · 1999 to 2010
$16.2M
HAPO: DATA COORDINATING CENTERR01HD034242 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DYER, ALAN R · 1999 to 2007
$3.0M
NICHD NIH HHS R01 HD034242NICHD NIH HHS R01 HD034243
6 · The paper itself

Abstract

Context: Vitamin D inadequacy is globally prevalent among pregnant women; however, its impact on pregnancy remains inconclusive. Objective: This study aims to explore the associations of maternal and umbilical cord serum 25-hydroxyvitamin D (25(OH)D) levels with pregnancy and neonatal outcomes. Method: We used archived serum samples from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study participants in the Hong Kong center and assayed maternal 25(OH)D levels at midgestation and umbilical cord 25(OH)D at birth using liquid chromatography-tandem mass spectroscopy. Data regarding pregnancy and perinatal outcomes were extracted from the HAPO study dataset and the hospital computerized medical system. Results: Only 247 (16.4%) mothers and 66 (5.0%) neonates met the criteria for vitamin D sufficiency (ie, 25(OH)D ≥ 75 nmol/L). The ratio of umbilical cord to maternal vitamin D levels was positively associated with maternal age and ambient solar radiation at the month of delivery, while negatively associated with maternal serum total 25(OH)D at midgestation (all Conclusion: Placental vitamin D transfer was found to be higher with a lower maternal vitamin D level, older maternal age, and higher ambient solar radiation at the time of the delivery. The protective effect of sufficient vitamin D in a cesarean section will require further studies.

Indexed as

maternalneonatal outcomesplacental transferpregnancy outcomesumbilical cordvitamin D

Identifiers

PMID38075561
PMCPMC10701472
OpenAlexW4388822303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.