ArticleFrontiers in endocrinology2023
Dissecting causal associations of type 2 diabetes with 111 types of ocular conditions: a Mendelian randomization study.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Effectiveness of Internet + E-Coach chronic disease management on blood glucose, lipid levels, liver function, and quality of life in patients with chronic diabetic retinopathy: a comparative study.BMC ophthalmology · 2024Trial
- Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits.Medicine · 2025Article
- The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities.Nature communications · 2025Article
- The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities.medRxiv : the preprint server for health sciences · 2025Article
- Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study.BMJ open ophthalmology · 2025Article
- Research progress of Mendelian randomization analysis for glaucoma etiology.International journal of ophthalmology · 2025Review
- Article
- Design, synthesis and inhibition evaluation of novel chalcone amide α-glucosidase inhibitors.Future medicinal chemistry · 2024Article
- An Exploration of Shared Risk Factors for Coronary Artery Disease and Cancer from 109 Traits: The Evidence from Two-Sample Mendelian Randomization Studies.Reviews in cardiovascular medicine · 2024Article
- α-Glucosidase inhibitory potential ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Environmental endocrine disruptor-induced mitochondrial dysfunction: a potential mechanism underlying diabetes and its complications.Frontiers in endocrinology · 2024Review
- Unveiling the causal link between metabolic factors and ovarian cancer risk using Mendelian randomization analysis.Frontiers in endocrinology · 2024Article
- Exploring the causal association between epigenetic clocks and menopause age: insights from a bidirectional Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives.Frontiers in cardiovascular medicine · 2024Review
- Assessment of potential risk factors associated with gestational diabetes mellitus: evidence from a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Endocrine and metabolic factors and the risk of idiopathic pulmonary fibrosis: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Sodium intake and the risk of various types of cardiovascular diseases: a Mendelian randomization study.Frontiers in nutrition · 2023Article
- Assessing causal associations of hyperparathyroidism with blood counts and biochemical indicators: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite the well-established findings of a higher incidence of retina-related eye diseases in patients with diabetes, there is less investigation into the causal relationship between diabetes and non-retinal eye conditions, such as age-related cataracts and glaucoma. Methods: We performed Mendelian randomization (MR) analysis to examine the causal relationship between type 2 diabetes mellitus (T2DM) and 111 ocular diseases. We employed a set of 184 single nucleotide polymorphisms (SNPs) that reached genome-wide significance as instrumental variables (IVs). The primary analysis utilized the inverse variance-weighted (IVW) method, with MR-Egger and weighted median (WM) methods serving as supplementary analyses. Results: The results revealed suggestive positive causal relationships between T2DM and various ocular conditions, including "Senile cataract" (OR= 1.07; 95% CI: 1.03, 1.11; Conclusion: Our evidence supports a causal relationship between T2DM and specific ocular disorders. This provides a basis for further research on the importance of T2DM management and prevention strategies in maintaining ocular health.
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